82495-51-0

Upstream product

• 88158-68-3 4-(tert-butyldiphenylsilyloxy)-1-butyne 
• 124-38-9 carbon dioxide 
• 158478-19-4 C₂₃H₃₀O₃Si 
• 35066-36-5 5-hydroxy-3-methyl-2-(E)-pentenoic acid methyl ester 
• 19710-84-0 5-hydroxy-3-methyl-2-(E)-pentenoic acid 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 82495-54-3 (E)-5-(tert-Butyl-diphenyl-silanyloxy)-1-imidazol-1-yl-3-methyl-pent-2-en-1-one 
• 1224926-52-6 C₄₃H₅₈N₂O₈Si 
• 76685-82-0 trichoverrin B 
• 82521-42-4 C₅₇H₈₆O₉Si₃ 

Relevant academic research and scientific papers

Cu-catalyzed formal methylative and hydrogenative carboxylation of alkynes with carbon dioxide: Efficient synthesis of α,β-unsaturated carboxylic acids

The sequential hydroalumination or methylalumination of various alkynes catalyzed by different catalyst systems, such those based on Sc, Zr, and Ni complexes, and the subsequent carboxylation of the resulting alkenylaluminum species with CO2 catalyzed by an N-heterocyclic carbene (NHC)-copper catalyst have been examined in detail. The regio- and stereoselectivity of the overall reaction relied largely on the hydroalumination or methylalumination reactions, which significantly depended on the catalyst and alkyne substrates. The subsequent Cu-catalyzed carboxylation proceeded with retention of the stereoconfiguration of the alkenylaluminum species. All the reactions could be carried out in one-pot to afford efficiently a variety of α,β- unsaturated carboxylic acids with well-controlled configurations, which are difficult to construct by previously reported methods. This protocol could be practically useful and attractive because of its high regio- and stereoselectivity, simple one-pot reaction operation, and the use of CO 2 as a starting material. Copyright

Synthesis of the trans-fusarinine scaffold

The trans-fusarinine backbone is a common feature encountered in many fungal siderophores. This monomer is notably the structural base of Nα-methyl coprogen B and dimerumic acid. Both siderophores are known to be secreted by Scedosporium apiosp

Synthesis of Trichoverrin B and Its Conversion to Verrucarin J

Anguidine (3b) was converted to verrucarol (3a), which in turn was selectively acylated to yield trichoverin B (2).Trichoverrin B reacts with pyridinium dichromate in dimethylformamide, via a novel oxidative ring closure, to give verrucarin J (11a) in 50 percent yield.