824982-83-4Relevant academic research and scientific papers
Conformational analysis of axially substituted 4,4′-bi-1,3-dioxanyls
Brandl, Trixi,Hoffmann, Reinhard W.
, p. 4373 - 4378 (2004)
In contrast to the simple 4,4′-bi-1,3-dioxanyl derivative 6, which has no conformational preference at the inter-ring bond, the derivatives 9 and 10, which have two strategically placed axial methyl groups, show conformational preferences exceeding 95 %.
Stereoselective approach to potential scaffold of A-nor B-aromatic OSW-1 analogues via [4+2] cycloaddition of o-quinodimethane
Li, Bozhi,Masuda, Seiji,Minato, Daishiro,Zhou, Dejun,Sugimoto, Kenji,Nemoto, Hideo,Matsuya, Yuji
, p. 3981 - 3987 (2014/06/09)
A-nor B-aromatic steroidal skeleton was efficiently constructed by means of o-quinodimethane chemistry with exclusive stereoselectivity. The benzocyclobutene substrate for generation of the o-quinodimethane intermediate and subsequent [4+2] cycloaddition could be synthesized via (E)-selective Julia-Kocienski olefination and diastereoselective Grignard addition reactions. The synthesized tricyclic steroid-like compound with a trans-diol substructure would be utilized for divergent syntheses of potentially antitumor OSW-1 analogues with the truncated steroidal aglycone.
