824984-08-9Relevant academic research and scientific papers
Catalytic asymmetric conjugate addition of dialkylzinc reagents to β-aryl-α,β-unsaturated N-2,4,6- triisopropylphenylsulfonylaldimines with use of N-Boc-L-Val-connected amidophosphane-copper(I) Catalyst
Soeta, Takahiro,Kuriyama, Masami,Tomioka, Kiyoshi
, p. 297 - 300 (2007/10/03)
(Chemical Equation Presented). Asymmetric conjugate addition of dialkylzinc to α,β-unsaturated N-2,4,6-triisopropylphenylsulfonylaldimines 9 was catalyzed by 5 mol % N-Boc-L-valine-connected amidophosphane 5a-Cu-(MeCN) 4BF4 in the presence of 4 A MS in toluene to afford, after hydrolysis of an imine to an aldehyde through a short alumina column and reduction with sodium borohydride, the corresponding β-alkylated alkanols 10 with 67-91% ee in reasonably high yields.
