824984-24-9Relevant articles and documents
CuH-Catalyzed Asymmetric Reduction of α,β-Unsaturated Carboxylic Acids to β-Chiral Aldehydes
Zhou, Yujing,Bandar, Jeffrey S.,Liu, Richard Y.,Buchwald, Stephen L.
, p. 606 - 609 (2018/01/26)
The copper hydride (CuH)-catalyzed enantioselective reduction of α,β-unsaturated carboxylic acids to saturated aldehydes is reported. This protocol provides a new method to access a variety of β-chiral aldehydes in good yields, with high levels of enantioselectivity and broad functional group tolerance. A reaction pathway involving a ketene intermediate is proposed based on preliminary mechanistic studies and density functional theory calculations.
Chiral γ-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents: Design, synthesis, structure, and in vitro fungicidal activities
Cao, Xiufang,Li, Fei,Hu, Ming,Lu, Wenchang,Yu, Guang-Ao,Sheng, Hua Liu
experimental part, p. 11367 - 11375 (2010/03/31)
A novel series of chiral γ-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents have been designed and synthesized conveniently by using the chiral auxiliary as a controlling reagent. All of the compounds exhibit moderate to high ee va
