825-16-1

Upstream product

• 1066-26-8 sodium acetylide 
• 823-76-7 Cyclohexyl methyl ketone 
• 75-20-7 calcium carbide 
• 74-86-2 acetylene 

Downstream Products

• 62614-92-0 3-cyclohexylidene-butan-2-one 
• 91055-75-3 (E)-3-cyclohexylbut-2-enal 
• 927808-33-1 2-cyclohexyl-penta-3,4-dien-2-ol 
• 927808-14-8 2-cyclohexylpenta-3,4-dien-2-yl acetate 
• 27608-07-7 3-cyclohexylbutanal 
• 1190417-17-4 (4-bromobuta-2,3-dien-2-yl)cyclohexane 
• 1310480-36-4 2-cyclohexylbut-3-yn-2-yl acetate 
• 1380546-48-4 C₁₅H₂₄O₂ 
• 1380546-56-4 4-cyclohexylpenta-2,3-dien-1-ol 
• 1380546-56-4 (R)-(+)-4-cyclohexyl-2,3-pentadienol 

Relevant academic research and scientific papers

Kinetic Resolution of Tertiary Propargylic Alcohols by Enantioselective Cu?H-Catalyzed Si?O Coupling

A broad range of tertiary propargylic alcohols were kinetically resolved by catalyst-controlled enantioselective silylation. This non-enzymatic kinetic resolution is catalyzed by a Cu?H species and makes use of the commercially available precatalyst MesCu/(R,R)-Ph-BPE and a simple hydrosilane as the resolving reagent. Both alkyl,aryl- as well as dialkyl-substituted propargylic alcohols participate, and especially high selectivity factors are achieved when the alkyne terminus carries a TIPS group, which also enables facile post-functionalization in this position (s up to 207).

Synthesis of acetylenic alcohols with calcium carbide as the acetylene source

Propargyl alcohols containing a terminal alkyne group are highly important and versatile intermediates. Here, we report the synthesis of these compounds from an inexpensive and renewable resource, calcium carbide (CaC2). No metal catalysts are required in this new protocol and the reactions take place under very mild conditions.