82500-35-4

Usage

Uses

Used in Pharmaceutical Industry:
1-Tetrahydrofurfuryl-piperazine is used as an intermediate in the synthesis of various pharmaceuticals for its antimicrobial and antioxidant properties, which are instrumental in controlling microbial growth and preventing oxidative damage in drug formulations.
Used in Agrochemical Industry:
In agrochemicals, 1-Tetrahydrofurfuryl-piperazine serves as an intermediate, leveraging its antimicrobial properties to develop products that protect crops from diseases and pests, thereby ensuring higher crop yields and quality.
Used in Corrosion Inhibition:
1-Tetrahydrofurfuryl-piperazine is used as a corrosion inhibitor, providing protection to metals from environmental degradation, thus extending the lifespan of materials used in various industries.
Used in Coatings and Adhesives Industry:
As a component in coatings and adhesives, 1-Tetrahydrofurfuryl-piperazine enhances the performance of these products by improving their resistance to microbial attack and oxidative stress, ensuring longer-lasting and more durable applications.
Used in Polymer Chemistry:
1-Tetrahydrofurfuryl-piperazine has potential applications in polymer chemistry, where it is used as a monomer in the synthesis of polymers. Its incorporation can lead to the development of new materials with improved properties, such as enhanced resistance to microbial growth and oxidative damage.

InChI:InChI=1/C9H18N2O/c1-2-9(12-7-1)8-11-5-3-10-4-6-11/h9-10H,1-8H2

Upstream product

• 3003-84-7 Tetrahydrofurfuryl chloride 
• 110-85-0 piperazine 
• 7681-84-7 tetrahydrofuran-2-carbaldehyde 

Downstream Products

• 1333167-64-8 5-(4-((tetrahydrofuran-2-yl)methyl)piperazin-1-yl)-5-(4-phenoxyphenyl)pyrimidine-2,4,6(1H,3H,5H)-trione 
• 1246193-66-7 C₂₄H₂₉FN₆O 
• 548768-55-4 4-(Tetrahydro-furan-2-ylmethyl)-piperazine-1-carboxylic acid 4-[2-(4-chloro-phenyl)-ethylcarbamoyl]-phenyl ester 
• 549510-88-5 4-(Tetrahydrofuran-2-ylmethyl)-piperazine-1-carboxylic acid 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester 
• 549510-82-9 4-(Tetrahydrofuran-2-ylmethyl)-piperazine-1-carboxylic acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl ester 

Relevant academic research and scientific papers

Tetrahydrofuranylmethylamines: An Efficient and Simple One-Step Synthesis and Biological Activities

Various tetrahydrofuran-2-ylmethylamines have been prepared in good yields by an efficient one-step synthesis utilizing the reaction of tetrahydrofurfurylchloride with different secondary cyclic amines without any catalyst. The compounds were tested for their in vitro affinity for the (α4)2(β2)3 and α7* nicotinic acetylcholine receptor (nAChR) subtypes. Pyrrolidine, piperidine and azepane containing analogs (1a, 1b, 1c) showed Ki values in the lower micromolar range for these neuronal nAChR subtypes in rat brain.

Discovery of Novel Apigenin-Piperazine Hybrids as Potent and Selective Poly (ADP-Ribose) Polymerase-1 (PARP-1) Inhibitors for the Treatment of Cancer

Poly (ADP-ribose) polymerase-1 (PARP-1) is a potential target for the discovery of chemosensitizers and anticancer drugs. Amentoflavone (AMF) is reported to be a selective PARP-1 inhibitor. Here, structural modifications and trimming of AMF have led to a series of AMF derivatives (9a-h) and apigenin-piperazine/piperidine hybrids (14a-p, 15a-p, 17a-h, and 19a-f), respectively. Among these compounds, 15l exhibited a potent PARP-1 inhibitory effect (IC50 = 14.7 nM) and possessed high selectivity to PARP-1 over PARP-2 (61.2-fold). Molecular dynamics simulation and the cellular thermal shift assay revealed that 15l directly bound to the PARP-1 structure. In in vitro and in vivo studies, 15l showed a potent chemotherapy sensitizing effect against A549 cells and a selective cytotoxic effect toward SK-OV-3 cells through PARP-1 inhibition. 15l·2HCl also displayed good ADME characteristics, pharmacokinetic parameters, and a desirable safety margin. These findings demonstrated that 15l·2HCl may serve as a lead compound for chemosensitizers and the (BRCA-1)-deficient cancer therapy.