82508-37-0

Basic information

• Product Name: Deacetylpseudolaric acid A
• Synonyms: Deacetylpseudolaric acid A
• CAS NO: 82508-37-0
• Molecular Formula: C20H26O5
• Molecular Weight: 346.4174
• Mol File: 82508-37-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 569.38 °C at 760 mmHg
• Flash Point: 202.266 °C
• Appearance: /
• Density: 1.249 g/cm³
• CAS DataBase Reference: Deacetylpseudolaric acid A(CAS DataBase Reference)
• NIST Chemistry Reference: Deacetylpseudolaric acid A(82508-37-0)
• EPA Substance Registry System: Deacetylpseudolaric acid A(82508-37-0)

Safety Data

• Hazardous Substances Data: 82508-37-0(Hazardous Substances Data)

Usage

General Description

Deacetylpseudolaric acid A is a natural product derived from the root bark of Pseudolarix kaempferi, a coniferous tree native to China. It belongs to the diterpene family of compounds and is known for its potent cytotoxic and anti-tumor activities. Studies have shown that Deacetylpseudolaric acid A exerts its anti-cancer effects by inducing apoptosis, inhibiting cell proliferation, and disrupting the cell cycle in various cancer cell lines. It has also been found to possess anti-inflammatory and immunosuppressive properties, making it a promising candidate for the development of novel anti-cancer drugs. Overall, Deacetylpseudolaric acid A shows great potential for the treatment of cancer and other inflammatory diseases.

Upstream product

• 82508-32-5 pseudolaric acid A 
• 915708-13-3 2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)-5-(4-methoxy-benzyloxymethyl)-8-methyl-11-oxa-tricyclo[5.3.1.0^1,5]undecan-8-ol 
• 915708-12-2 2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)-5-(4-methoxy-benzyloxymethyl)-11-oxa-tricyclo[5.3.1.0^1,5]undecan-8-one 
• 915708-14-4 8-chloro-2-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)-5-(4-methoxy-benzyloxymethyl)-8-methyl-11-oxa-tricyclo[5.3.1.0^1,5]undecane 
• 915708-15-5 3-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)-8a-(4-methoxy-benzyloxymethyl)-6-methyl-2,3,4,5,8,8a-hexahydro-1H-azulen-3a-ol 
• 915708-16-6 3-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)-8a-hydroxymethyl-6-methyl-2,3,4,5,8,8a-hexahydro-1H-azulen-3a-ol 
• 915708-21-3 1-(2,2-diethyl-4-methyl-[1,3]dioxolan-4-yl)-8a-hydroxy-6-methyl-2,3,4,7,8,8a-hexahydro-1H-azulene-3a-carbaldehyde 

Downstream Products

• 82508-32-5 pseudolaric acid A 

Relevant articles and documents

Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism

Pseudolaric acid A (PAA), one of the main bioactive ingredients in traditional medicine Pseudolarix cortex, exhibits remarkable anticancer activities. Yet its mechanism of action and molecular target have not been investigated and remain unclear. In this work, mechanistic study showed that PAA induced cell cycle arrest at G2/M phase and promoted cell death through caspase-8/caspase-3 pathway, demonstrating potent antiproliferation and anticancer activities. PAA was discovered to be a new Hsp90 inhibitor and multiple biophysical experiments confirmed that PAA directly bind to Hsp90. Active PAA-probe was designed, synthesized and biological evaluated. It was subsequently employed to verify the cellular interaction with Hsp90 in HeLa cells through photoaffinity labeling approach. Furthermore, NMR experiments showed that N-terminal domain of Hsp90 and essential groups in PAA are important for the protein-inhibitor recognition. Structure-activity relationship studies revealed the correlation between its Hsp90 inhibitory activity with anticancer activity. This work proposed a potential mechanism involved with the anticancer activity of PAA and will improve the appreciation of PAA as a potential cancer therapy candidate.