82527-10-4

Upstream product

• 141345-70-2 Ac-Phe-MeA-MeA-MeA-OBu^t 
• 4576-16-3 2-(1'-((benzyloxycarbonyl)amino)-1'-methylethyl)-4,4-dimethyloxazolone 
• 1161-13-3 N-Cbz-L-Phe 
• 79775-03-4 2-<2-(Benzyloxycarboxamido)-2-methylpropionamido>-2-methylpropionsaeure 
• 4512-37-2 Z-MeA-MeA-MeA-OBu^t 
• 41518-17-6 Z-Phe-O-COO-isoBu 
• 83537-94-4 Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester 
• 50559-88-1 (α-methylalanyl)2-α-methylalanine t-butyl ester 
• 141374-95-0 H-Phe-MeA-MeA-MeA-OBu^t 
• 141345-69-9 Z-Phe-MeA-MeA-MeA-OBu^t 

Downstream Products

• 141345-71-3 Ac-Phe-MeA-MeA-MeA-Val-Gly-OBzl 
• 141345-83-7 Ac-Phe-MeA-MeA-MeA-Val-Gly-OH 

Relevant academic research and scientific papers

Attempts toward the synthesis of the peptaibol antiamoebin by using the 'azirine/oxazolone method'

The two segments, 1-9 and 10-16, of the peptaibol antibiotic antiamoebin I, i.e., the nonapeptide Ac-Phe-Aib-Aib-Aib-D,L-Iva-Gly-Leu-Aib-Aib-OH (15) and the heptapeptide Z-Hyp-Gln-D,L-Iva-Hyp-Aib-Pro-Pheol (34), have been prepared as mixtures of the epimers containing D,L-Iva. All α,α-disubstituted α-amino acids were introduced by the 'azirine/oxazolone method', in which amino or peptide acids are coupled with the corresponding 2H-azirin-3-amines, followed by selective hydrolysis of the terminal amide bond. The amino acids Hyp and Gln were introduced as Z-protected4) (2S,4R)-4-(tert-butoxy) proline (19) and methyl N-[bis(4-methoxyphenyl)methyl]glutamine (26). Coupling of peptide segments was achieved via the 'mixed anhydride' method, the DCC/HOBt or TBTU/HOBt strategy. The crystal structure of the segment 6-9 was determined by X-ray crystallography and displayed the presence of a β-turn conformation. Copyright

Emerimicins III and IV and their ethylalanine12 epimers. Facilitated chemical-enzymatic synthesis and a qualitative evaluation of their solution structures

The peptaibol antibiotics, emerimicin III and IV (Ac-Phe1-MeA2-MeA3-MeA4-VaI 5-Gly6-Leu7-MeA8-MeA 9-Hyp10-Gln11-R-EtA12-Hyp