82543-16-6

Basic information

• Product Name: 3b,5-Dihydroxy-6b,7b:15b,16b-dimethylene-5b-androstan-17-one
• Synonyms: 3beta,5beta-dihydroxy-6beta,7beta;(2S,4aR,4bS,6aS,7aS,8aS,8bS,8cR,8dR,9aR,9bR);-2,9b-Dihydroxy-4a,6a-dimethylhexadecahydro-1H-cyclopropa[4,5]cyclopenta[1,2-a]cyclopropa[l]phenanthren-7(7aH);[3S-(3a,5a,6b,7b,8a,9b,10a,13a,14b,15b,16b)]-octadecahydro-3,5-dihydroxy-10,13-dimethyl-17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthren-17-one;6b,7b,15b,16b-Dimethylene-3b,5b-dihydroxyandrostan-17-one;3B,5-DIHYDROXY-6B,7B:15B,16B-DIMETHYLENE-5B-ANDROSTAN-17-ONE;3,5-DIHYDROXY-6,7:15,16-DIMETHYLENE-5-ANDROSTAN-17-ONE;[3S-(3a,5a,6,7,8a,9,10a,13a,14,15,16)]-octadecahydro-3,5-dihydroxy-10,13-dimethyl-17H-dicyclopropa[6,7:15,16]cyclopenta[a]phenanthren-17-one
• CAS NO: 82543-16-6
• Molecular Formula: C₂₁H₃₀O₃
• Molecular Weight: 330.46
• EINECS: 1308068-626-2
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
• Mol File: 82543-16-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 205-207°C
• Boiling Point: 478.278 °C at 760 mmHg
• Flash Point: 257.163 °C
• Appearance: white solid
• Density: 1.286 g/cm³
• Vapor Pressure: 4.37E-11mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.59±0.70(Predicted)
• CAS DataBase Reference: 3b,5-Dihydroxy-6b,7b:15b,16b-dimethylene-5b-androstan-17-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3b,5-Dihydroxy-6b,7b:15b,16b-dimethylene-5b-androstan-17-one(82543-16-6)
• EPA Substance Registry System: 3b,5-Dihydroxy-6b,7b:15b,16b-dimethylene-5b-androstan-17-one(82543-16-6)

Safety Data

• Hazardous Substances Data: 82543-16-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 82543-16-6 differently. You can refer to the following data:
1. Intermediate of Drospirenone
2. Intermediate of Drospirenone.

InChI:InChI=1/C21H32O3/c1-19-8-7-16-15(17(19)13-3-4-14(13)18(19)23)6-10-21(24)11-12(22)5-9-20(16,21)2/h12-17,22,24H,3-11H2,1-2H3/t12-,13+,14-,15+,16-,17-,19-,20+,21-/m0/s1

Upstream product

• 75-11-6 diiodomethane 
• 82543-15-5 3β,5-dihydroxy-15β,16β-methylene-5β-androst-6-en-17-one 
• 74-95-3 1,1-dibromomethane 
• 82543-09-7 7β-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5-androsten-17-one 
• 82543-13-3 7α-chloro-5,6β-epoxy-15β,16β-methylene-3β-pivaloyloxy-5β-androstan-17-one 
• 82544-13-6 5,6β-epoxy-7β-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androstan-17-one 
• 82543-14-4 5-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androst-6-en-17-one 
• 82543-07-5 3β,7β-dihydroxy-15β,16β-methylene-5-androsten-17-one 
• 67372-65-0 3β-hydorxy-15β,16β-methylene androst-5-ene-17-one 

Downstream Products

• 90457-65-1 dihydrospirorenone 
• 74220-07-8 Spirorenone 
• 1094603-82-3 6β,7β;15β,16β-dimethylene-17α-(3-benzyloxypropynyl)androstane-3β,5β,17β-triol 
• 82543-17-7 17α-(3-hydroxy-1-propinyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol 
• 1248589-64-1 C₃₀H₄₈O₄Si 

Relevant articles and documents

Process for the preparation of Drospirenone

A process for the preparation of Drospirenone (I) according to the following scheme wherein the substituent R is defined in the description. The process improves the product yield and purity by reducing the formation of undesired side-products and is particularly convenient for industrial-scale manufacturing.

A process for the preparation of drospirenone

A process is described for preparing drospirenone, a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for the preparation of pharmaceutical compositions with contraceptive action, starting from 5,6β-epoxy-7β-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androstan-17-one.