825612-38-2

Upstream product

• 609-73-4 o-nitroiodobenzene 
• 4381-25-3 (S)-S-methyl-S-phenylsulfoximine 
• 577-19-5 2-nitrophenyl bromide 
• 825612-37-1 (S)-N-(2-nitrophenyl)-S-methyl-S-phenylsulfoximine 

Downstream Products

• 825612-43-9 (S)-N-[2-(2,4,6-triisopropylbenzylamino)phenyl]-S-methyl-S-phenylsulfoximine 
• 1228444-76-5 (S)-N-[2-(2-1H-pyrrolylmethyl)aminophenyl]-S-methyl-S-phenylsulfoximine 
• 1228444-69-6 (S)-N-[2-(2,3,4,5,6-pentafluorobenzyl)aminophenyl]-S-methyl-S-phenylsulfoximine 
• 1228444-74-3 (S)-N-[2-(2-phenylbenzyl)aminophenyl]-S-methyl-S-phenylsulfoximine 
• 1228444-73-2 (S)-N-[2-(4-nitrobenzyl)aminophenyl]-S-methyl-S-phenylsulfoximine 
• 1228444-72-1 (S)-N-[2-(3-methoxybenzyl)aminophenyl]-S-methyl-S-phenylsulfoximine 
• 1228444-70-9 C₂₈H₂₄N₂OS 
• 1602489-95-1 (S)-N-{2-[(3,5-di-tert-butyl-2-hydroxybenzyl)amino]phenyl}-S-methyl-S-phenylsulfoximine 
• 1602489-98-4 (S,E)-N-[2-(2,4,6-triisopropylbenzylidene)aminophenyl]-S-methyl-S-phenylsulfoximine 
• 1408337-18-7 (S)-N-[3,5-bis(trifluoromethyl)phenyl]-N’-[2’-(S-methyl-S-phenylsulfonimidoyl)phenyl]thiourea 
• 1408337-19-8 (S)-N-[2-(S-methyl-S-phenylsulfonimidoyl)phenyl]-N'-phenylthiourea 

Relevant academic research and scientific papers

Synthesis of chiral sulfoximine-based thioureas and their application in asymmetric organocatalysis

For the first time, chiral sulfoximine derivatives have been applied as asymmetric organocatalysts. In combination with a thioureatype backbone the sulfonimidoyl moiety leads to organocatalysts showing good reactivity in the catalytic desymmetrization of a cyclic meso-anhydride and moderate enantioselectivity in the catalytic asymmetric Biginelli reaction. Straightforward synthetic routes provide the newly designed thiourea-sulfoximine catalysts in high overall yields without affecting the stereohomogeneity of the sulfur-containing core fragment.

C1-Symmetric aminosulfoximines in copper-catalyzed asymmetric vinylogous mukaiyama aldol reactions

Vinylogous Mukaiyama-type aldol reactions have been catalyzed by a combination of Cu(OTf)2 and readily available C1-symmetric aminosulfoximines. After a fine-tuning of the reaction conditions and an optimization of the modularly assembled ligand structure, high stereoselectivities and excellent yields have been achieved in catalyzed reactions involving various electrophile/nucleophile combinations. The relative and absolute configurations of two products were assigned by X-ray single crystal structure analysis and a comparison of calculated and experimental CD spectra.

Highly modular synthesis of C1-symmetric aminosulfoximines and their use as ligands in copper-catalyzed asymmetric Mukaiyama-Aldol reactions

The development of C1-symmetric aminosulfoximines, their highly modular synthesis, and their application in enantioselective copper-catalyzed Mukaiyama-type aldol reactions between pyruvates and enolsilanes is described. In this context, the in

C1-symmetric aminosulfoximines as ligands in copper-catalyzed carbonyl-ene reactions

Highly modular C1-symmetric aminosulfoximines were prepared and applied as chiral ligands in copper-catalyzed enantioselective carbonyl-ene reactions. The optimized system catalyzed the conversion of pyruvates and 1,1-disubstituted olefins yiel

C1-symmetric sulfoximines as ligands in copper-catalyzed asymmetric mukaiyama-type aldol reactions

Aldol products with quarternary centers have been obtained with up to 99% ee in high yields by using copper(II) catalysts bearing C1-symmetric aminosulfoximines as ligands (see scheme). In terms of ee values and yield the new catalysts compare