825631-79-6Relevant articles and documents
Synthesis and pharmacological evaluation of 1,2,4-benzothiadiazin-1,1- dioxides bearing 5- or 7-sulfonylurea moieties
Khelili, Smail,Faury, Gilles,Nicolle, Edwige,Verdetti, Jean,Leclerc, Gerard
, p. 457 - 470 (2007/10/03)
A series of substituted benzothiadiazin-1,1-dioxides bearing sulfonylurea moieties in position 5 or 7 has been synthesized. The most powerful vasodilator compound was 18a, obtained by substitution of a sulfonylurea moiety on position 7 of the diazoxide skeleton by means of a SO2 group. Interestingly, 18a and 18b were found inactive on insulin secretion at 50 μM and likely devoid of adverse effect on glycemia, suggesting a special therapeutic potential for these compounds.