825634-83-1

Upstream product

• 154715-77-2 tert-butyl 2,5-dihydroxybenzoate 
• 637-69-4 4-Methoxystyrene 
• 74-88-4 methyl iodide 
• 1019652-03-9 (2S)-2-(2-bromo-5-methoxy-phenyl)-1-(4-methoxy-phenyl)-ethanol 

Relevant academic research and scientific papers

Enantioselective Construction of 2-Aryl-2,3-dihydrobenzofuran Scaffolds Using Cu/SPDO-Catalyzed [3 + 2] Cycloaddition

A new, efficient approach toward the preparation of 2-aryl-2,3-dihydrobenzofuran scaffolds through the Cu/SPDO-catalyzed [3 + 2] cycloaddition between quinone ester and styrene derivatives has been developed. The procedure features excellent enantioselectivities (up to 99% ee), high yields (up to 96%), and broad substrate tolerance. Additionally, asymmetric synthesis of natural corsifurans A and B from commercially available starting materials has also been achieved in two or three steps using this reaction as a key transformation.

Asymmetric synthesis of corsifuran A by an enantioselective oxazaborolidine reduction

(Chemical Equation Presented) Corsifuran A has been prepared in an enantiomerically pure form for the first time by an asymmetric reduction procedure, allowing confirmation of the absolute stereochemistry of the natural product as (R).