82585-71-5

Basic information

• Product Name: ethyl [6-amino-4-({(2E)-2-(hydroxyimino)-2-[4-(trifluoromethyl)phenyl]ethyl}amino)-5-nitropyridin-2-yl]carbamate
• CAS NO: 82585-71-5
• Molecular Formula: C₁₇H₁₇F₃N₆O₅
• Molecular Weight: 442.3493
• Mol File: 82585-71-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 604.2°C at 760 mmHg
• Flash Point: 319.2°C
• Density: 1.55g/cm³
• Vapor Pressure: 1.9E-15mmHg at 25°C
• Refractive Index: 1.61
• CAS DataBase Reference: ethyl [6-amino-4-({(2E)-2-(hydroxyimino)-2-[4-(trifluoromethyl)phenyl]ethyl}amino)-5-nitropyridin-2-yl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl [6-amino-4-({(2E)-2-(hydroxyimino)-2-[4-(trifluoromethyl)phenyl]ethyl}amino)-5-nitropyridin-2-yl]carbamate(82585-71-5)
• EPA Substance Registry System: ethyl [6-amino-4-({(2E)-2-(hydroxyimino)-2-[4-(trifluoromethyl)phenyl]ethyl}amino)-5-nitropyridin-2-yl]carbamate(82585-71-5)

Safety Data

• Hazardous Substances Data: 82585-71-5(Hazardous Substances Data)

Upstream product

• 82585-55-5 2-[2-[(E)-Hydroxyimino]-2-(4-trifluoromethyl-phenyl)-ethyl]-isoindole-1,3-dione 
• 6506-86-1 ethyl (6-amino-4-chloro-5-nitropyridin-2-yl)carbamate 
• 82585-42-0 2-Amino-1-(4-trifluoromethyl-phenyl)-ethanone oxime 

Downstream Products

• 82586-03-6 [5-Amino-3-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl]-carbamic acid ethyl ester 
• 82585-84-0 {6-Amino-5-nitro-4-[2-oxo-2-(4-trifluoromethyl-phenyl)-ethylamino]-pyridin-2-yl}-carbamic acid ethyl ester 

Relevant articles and documents

New Anticancer Agents: Synthesis of 1,2-Dihydropyridopyrizines (1-Deaza-7,8-dihydropteridines)

Reaction of α-aminoacetophenone oximes (2) with ethyl 6-amino-4-chloro-5-nitropyridine-2-carbamate (1) gave ethyl 6-amino-5-nitro-4-pyridine-2-carbamate oximes (3), which were hydrolyzed under acidic conditions to give the corresponding ketones (4).Related pyridines substituted with keto side chain were prepared from 1 and 1,3-diaminopropanone oximes and by oxidation of the side-chain hydroxy group of ethyl 6-amino-4-amino>-5-nitropyridine-7-carbamates (6).Catalytic hydrogenation of the nitro group of 4 over Raney nickel in a large volume of ethanol gave the 1-deaza-7,8-dihydropteridines (7).Several of the oximes 3 were successfully hydrogenated to give 7 directly.The resulting 1-deaza-7,8-dihydropteridines showed potent cytotoxicity against cultured L1210 cells and significant anticancer activity against lymphocytic leukemia P-388 in mice.THese biological activities are attributed to the accumulation of cells at mitosis.