82585-42-0

Basic information

• Product Name: (1Z)-2-amino-1-[4-(trifluoromethyl)phenyl]ethanone oxime
• CAS NO: 82585-42-0
• Molecular Formula: C₉H₉F₃N₂O
• Molecular Weight: 218.1758
• Mol File: 82585-42-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 289°C at 760 mmHg
• Flash Point: 128.6°C
• Density: 1.34g/cm³
• Vapor Pressure: 0.00105mmHg at 25°C
• Refractive Index: 1.497
• CAS DataBase Reference: (1Z)-2-amino-1-[4-(trifluoromethyl)phenyl]ethanone oxime(CAS DataBase Reference)
• NIST Chemistry Reference: (1Z)-2-amino-1-[4-(trifluoromethyl)phenyl]ethanone oxime(82585-42-0)
• EPA Substance Registry System: (1Z)-2-amino-1-[4-(trifluoromethyl)phenyl]ethanone oxime(82585-42-0)

Safety Data

• Hazardous Substances Data: 82585-42-0(Hazardous Substances Data)

Usage

General Description

The chemical compound (1Z)-2-amino-1-[4-(trifluoromethyl)phenyl]ethanone oxime is a oxime of 2-amino-1-(4-(trifluoromethyl)phenyl)ethanone, which is a ketone containing a trifluoromethyl group and a phenyl group. It is used in organic synthesis and pharmaceutical research as a building block for the synthesis of various compounds. Its structure and properties make it a valuable intermediate in the production of pharmaceuticals and agrochemicals. Its oxime form adds versatility to its use in chemical reactions, and it has potential applications in medicinal chemistry for the synthesis of novel compounds with diverse biological activities.

Upstream product

• 82585-55-5 2-[2-[(E)-Hydroxyimino]-2-(4-trifluoromethyl-phenyl)-ethyl]-isoindole-1,3-dione 

Downstream Products

• 82585-84-0 {6-Amino-5-nitro-4-[2-oxo-2-(4-trifluoromethyl-phenyl)-ethylamino]-pyridin-2-yl}-carbamic acid ethyl ester 
• 82586-03-6 [5-Amino-3-(4-trifluoromethyl-phenyl)-1,2-dihydro-pyrido[3,4-b]pyrazin-7-yl]-carbamic acid ethyl ester 
• 82585-71-5 {6-Amino-4-[2-[(Z)-hydroxyimino]-2-(4-trifluoromethyl-phenyl)-ethylamino]-5-nitro-pyridin-2-yl}-carbamic acid ethyl ester 

Relevant articles and documents

New Anticancer Agents: Synthesis of 1,2-Dihydropyridopyrizines (1-Deaza-7,8-dihydropteridines)

Reaction of α-aminoacetophenone oximes (2) with ethyl 6-amino-4-chloro-5-nitropyridine-2-carbamate (1) gave ethyl 6-amino-5-nitro-4-pyridine-2-carbamate oximes (3), which were hydrolyzed under acidic conditions to give the corresponding ketones (4).Related pyridines substituted with keto side chain were prepared from 1 and 1,3-diaminopropanone oximes and by oxidation of the side-chain hydroxy group of ethyl 6-amino-4-amino>-5-nitropyridine-7-carbamates (6).Catalytic hydrogenation of the nitro group of 4 over Raney nickel in a large volume of ethanol gave the 1-deaza-7,8-dihydropteridines (7).Several of the oximes 3 were successfully hydrogenated to give 7 directly.The resulting 1-deaza-7,8-dihydropteridines showed potent cytotoxicity against cultured L1210 cells and significant anticancer activity against lymphocytic leukemia P-388 in mice.THese biological activities are attributed to the accumulation of cells at mitosis.