826-39-1 Usage
Description
Mecamylamine hydrochloride is a non-competitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50 range from 1-7 μM), previously used to treat hypertension.Displays antidepressant-like effects in mice.Mecamylamine HCl is supplied as tablets for oral use, each containing 2.5 mg mecamylamine HCl. Inactive ingredients are calcium phosphate, D&C Yellow 10, FD&C Yellow 6, lactose, magnesium stearate, cornstarch, and talc.
Chemical Properties
Mecamylamine hydrochloride is a white, odorless, or practically odorless, crystalline powder, is highly stable, soluble in water and has a molecular weight of 203.75.
Uses
Different sources of media describe the Uses of 826-39-1 differently. You can refer to the following data:
1. Mecamylamine hydrochloride has been used as an additive in extracellular saline during current-clamp recordings to reduce synaptic input. It has also been used as a non-selective nicotinic acetyl choline receptor blocker in aortic body neurons and in MLO-Y4 cells.
2. Mecamylamine is a noncompetitive nicotinic acetylcholine receptor antagonist with preferential activity at the α3β4 subtype (IC50 = 90-640 nM) compared to α4β2, α3β2, and α7 subtypes (IC50s range from 1-7 μM). Mecamylamine is widely used as a broad-spectrum antagonist of neuronal nicotinic acetylcholine receptors in basic nicotine research. It has been reported to be effective as an aid to smoking cessation and may also be of use in various nicotine-responsive, neuropsychiatric disorders.[Cayman Chemical]
3. A noncompetitive nicotinic AChR inhibitor.
Therapeutic Function
Antihypertensive
General Description
The secondary aminemecamylamine hydrochloride, N,2,3,3-tetramethyl-2-norbornanaminehydrochloride (Inversine), has a powerful ganglionicblocking effect that is almost identical to that ofhexamethonium. It has an advantage over most of the ganglionicblocking agents in being absorbed readily andsmoothly from the GI tract. It is rarely used, however, forthe treatment of moderate-to-severe hypertension becausesevere orthostatic hypotension occurs when the drug blockssympathetic ganglia.
Biological Activity
Non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.
Biochem/physiol Actions
Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier.
Metabolism
Mecamylamine hydrochloride (Inversine) is a secondary
amine and can therefore easily penetrate cell membranes.
Its absorption from the gastrointestinal tract is more complete
than that of the quaternary ammonium compounds.
Mecamylamine is well absorbed orally and crosses both
the blood-brain and placental barriers; its distribution is
not confined to the extracellular space. High concentrations
of the drug accumulate in the liver and kidney, and
it is excreted unchanged by the kidney. In contrast to most
of the highly ionized ganglionic blocking agents, mecamylamine
can produce central nervous system effects, including
tremors, mental confusion, seizures, mania, and
depression.The mechanism by which these central effects
are produced is unclear.Mecamylamine is rarely used today
as an antihypertensive drug because it blocks both
parasympathetic and sympathetic ganglia.
Check Digit Verification of cas no
The CAS Registry Mumber 826-39-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,2 and 6 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 826-39:
(5*8)+(4*2)+(3*6)+(2*3)+(1*9)=81
81 % 10 = 1
So 826-39-1 is a valid CAS Registry Number.
InChI:InChI=1/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H
