Products Categories
CAS No.: | 826-39-1 |
---|---|
Name: | Mecamylamine hydrochloride |
Molecular Structure: | |
Formula: | C11H21N.HCl |
Molecular Weight: | 203.79 |
Synonyms: | 2-Norbornanamine,N,2,3,3-tetramethyl-, hydrochloride (8CI);Bicyclo[2.2.1]heptan-2-amine,N,2,3,3-tetramethyl-, hydrochloride (9CI);CPDD 0059;Inversine;Mecamylaminechloride;Mevasin;Mevasine;N,2,3,3-Tetramethyl-2-norbornanamine hydrochloride; |
EINECS: | 212-555-8 |
Melting Point: | >240 °C (dec.) |
Boiling Point: | 189.3 °C at 760 mmHg |
Flash Point: | 58.1 °C |
Solubility: | ethanol: 122 mg/mL |
Appearance: | white solid |
Hazard Symbols: | Xn |
Risk Codes: | 22-36/37/38 |
Safety: | 36/37/39 |
Transport Information: | UN 2811 6.1/PG 3 |
PSA: | 12.03000 |
LogP: | 3.61350 |
(+/-)-exo-mecamylamine hydrochloride
(S)-phenylethyl isocyanate
B
(1R,2R,4S)-N-<((S)-1-phenylethyl)carbamoyl>mecamylamine
Conditions | Yield |
---|---|
With sodium carbonate 2.) CHCl3, 1 h, room t.; Yield given. Multistep reaction. Yields of byproduct given; |
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In tetrahydrofuran; N,N-dimethyl-formamide Alkylation; Heating; |
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In tetrahydrofuran; N,N-dimethyl-formamide Alkylation; Heating; |
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In tetrahydrofuran; N,N-dimethyl-formamide Alkylation; Heating; |
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In tetrahydrofuran; N,N-dimethyl-formamide Alkylation; Heating; |
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In tetrahydrofuran; N,N-dimethyl-formamide Alkylation; Heating; |
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In tetrahydrofuran; N,N-dimethyl-formamide Alkylation; Heating; |
Conditions | Yield |
---|---|
With potassium hydrogencarbonate In tetrahydrofuran; N,N-dimethyl-formamide Alkylation; Heating; |
(+/-)-exo-mecamylamine hydrochloride
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) aq. Na2CO3 / 2.) CHCl3, 1 h, room t. 2: 64 percent / ethanol / 0.75 h / Heating View Scheme |
What can I do for you?
Get Best Price
Chemistry informtion about Mevasin Hydrochloride (CAS NO.826-39-1) is:
IUPAC Name: N,5,6,6-Tetramethylbicyclo[2.2.1]Heptan-5-Amine Hydrochloride
Synonyms: N,2,3,3-Tetramethylbicyclo[2.2.1]Heptan-2-Amine Hydrochloride ; Inversine ; Mecamylamine ; Mecamylamine Hydrochloride ; 2-[Methylamino]Isocamphane Hydrochloride ; 3-Methylaminoisocamphanehydrochloride ; 3-Methylaminoisokamfanchlorid ; Inversinehydrochloride
Product Categories: Acetylcholine receptor
MF: C11H22ClN
MW: 203.75
EINECS: 212-555-8
Flash Point: 58.1 °C
Boiling Point: 189.3 °C at 760 mmHg
Vapour Pressure: 0.573 mmHg at 25°C
Enthalpy of Vaporization: 42.55 kJ/mol
Solubility ethanol: 122 mg/mL
Following is the molecular structure of Mevasin Hydrochloride (CAS NO.826-39-1) is:
Mevasin Hydrochloride (CAS NO.826-39-1) has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool. It is also sometimes used as an anti-addictive drug to help people stop smoking tobacco, and is now more widely used for this application than it is for lowering blood pressure. This effect is thought to be due to it blocking α3β4 nicotinic receptors in the brain.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | intraperitoneal | 63mg/kg (63mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 117, Pg. 169, 1956. | |
guinea pig | LD50 | oral | 175mg/kg (175mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 117, Pg. 169, 1956. | |
guinea pig | LD50 | subcutaneous | 155mg/kg (155mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 117, Pg. 169, 1956. | |
mouse | LD50 | intraperitoneal | 17mg/kg (17mg/kg) | Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 300, 1970. | |
mouse | LD50 | intravenous | 14mg/kg (14mg/kg) | Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 300, 1970. | |
mouse | LD50 | oral | 92mg/kg (92mg/kg) | Drugs in Japan Vol. 6, Pg. 814, 1982. | |
mouse | LD50 | subcutaneous | 81mg/kg (81mg/kg) | Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 300, 1970. | |
rat | LD50 | intraperitoneal | 53mg/kg (53mg/kg) | Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 301, 1970. | |
rat | LD50 | intravenous | 21mg/kg (21mg/kg) | Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 300, 1970. | |
rat | LD50 | oral | 208mg/kg (208mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 117, Pg. 169, 1956. | |
rat | LD50 | subcutaneous | 177mg/kg (177mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 117, Pg. 169, 1956. |
Poison by ingestion, intraperitoneal, intravenous, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Hazard Codes:
Xn
Risk Statements:
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements:
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: RB6900000
Biochem/physiol actions is Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier. Caution solutions are stable to autoclaving.