82603-64-3

Basic information

• Product Name: 6-(2,4-Dioxo-1,4-dihydroquinazolin-3(2H)-yl)-hexanoic acid
• Synonyms: 6-(2,4-Dioxo-1,4-dihydroquinazolin-3(2H)-yl)-hexanoic acid;6-(2,4-diketo-1H-quinazolin-3-yl)hexanoic acid;6-(2,4-dioxo-1H-quinazolin-3-yl)hexanoic acid;BB_SC-3324;6-(2,4-dioxo-1,2,3,4-tetrahydroquinazolin-3-yl)hexanoic acid;6-(2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)hexanoic acid;6-(2,4-Dioxo-1,4-dihydro-2H-quinazolin-3-yl)-hexanoic acid
• CAS NO: 82603-64-3
• Molecular Formula: C₁₄H₁₆N₂O₄
• Molecular Weight: 276.28784
• Mol File: 82603-64-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-(2,4-Dioxo-1,4-dihydroquinazolin-3(2H)-yl)-hexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(2,4-Dioxo-1,4-dihydroquinazolin-3(2H)-yl)-hexanoic acid(82603-64-3)
• EPA Substance Registry System: 6-(2,4-Dioxo-1,4-dihydroquinazolin-3(2H)-yl)-hexanoic acid(82603-64-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 82603-64-3(Hazardous Substances Data)

Upstream product

• 118-48-9 isatoic anhydride 
• 79-22-1 methyl chloroformate 
• 60-32-2 6-aminohexanoic acid 

Relevant articles and documents

(2-Amino-phenyl)-amides of ω-substituted alkanoic acids as new histone deacetylase inhibitors

A variety of ω-substituted alkanoic acid (2-amino-phenyl)-amides were designed and synthesized. These compounds were shown to inhibit recombinant human histone deacetylases (HDACs) with IC50 values in the low micromolar range and induce hyperacetylation of histones in whole cells. They induced expression of p21WAF1/Cip1 and caused cell-cycle arrest in human cancer cells. Compounds in this class showed efficacy in human tumor xenograft models.