82605-83-2Relevant academic research and scientific papers
ACYCLIC HYDRAZIDES AS CANNABINOID RECEPTOR MODULATORS
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Page/Page column 40, (2010/11/08)
The acyclic hydrazides of the invention are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present inventio
Benzylamines: Synthesis and evaluation of antimycobacterial properties
Meindl,Von Angerer,Schonenberger,Ruckdeschel
, p. 1111 - 1118 (2007/10/02)
The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra are described. The most active compounds in this test, N-methyl-3-chlorobenzylamine (MIC 10.2 μg/mL), N-methyl-3,5-dichlorobenzylamine (93, MIC 10.2 μg/mL), and N-butyl-3,5-difluorobenzylamine (MIC 6.4 μg/mL), also exhibited a marked inhibitory effect on Mycobacterium marinum and Mycobacterium lufu used for the determination of antileprotic properties. The combination of 93 with aminosalicylic acid, streptomycin, or dapsone exert marked supra-additive effects on M. tuberculosis H 37 Ra.
Reaction of Thiiranes with Azomethine Compounds
Sokolov, V. V.,Ogloblin, K. A.,Potekhin, A. A.
, p. 470 - 475 (2007/10/02)
Thiiranes add to imines and oximes to give thiazolidines.The addition of asymmetrical thiiranes is regioselective.The reaction of derivatives of asymmetrical carbonyl compounds with methylthiirane leads to mixtures of cis and trans stereoisomers of thiazo
