82605-84-3Relevant academic research and scientific papers
Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors
Yin, Yan,Lin, Li,Ruiz, Claudia,Khan, Susan,Cameron, Michael D.,Grant, Wayne,Pocas, Jennifer,Eid, Nibal,Park, Hajeung,Schr?ter, Thomas,Lograsso, Philip V.,Feng, Yangbo
supporting information, p. 3568 - 3581 (2013/06/27)
RhoA and its downstream effector ROCK mediate stress fiber formation and cell contraction through their effects on the phosphorylation of myosin light chain (MLC). Inhibition of the RhoA/ROCK pathway has proven to be a promising strategy for several indications such as cardiovascular disease, glaucoma, and inflammatory disease. In 2010, our group reported urea-based ROCK inhibitors as potential antiglaucoma agents. These compounds showed potent IC50 values in enzymatic and cell-based assays and significant intraocular pressure (IOP)-lowering effects in rats (～7 mmHg).(22) To develop more advanced ROCK inhibitors targeting various potential applications (such as myocardial infarction, erectile dysfunction, multiple sclerosis, etc.) in addition to glaucoma, a thorough SAR for this urea-based scaffold was studied. The detailed optimization process, counter-screening, and in vitro and in vivo DMPK studies are discussed. Potent and selective ROCK inhibitors with various in vivo pharmacokinetic properties were discovered.
Reaction of Thiiranes with Azomethine Compounds
Sokolov, V. V.,Ogloblin, K. A.,Potekhin, A. A.
, p. 470 - 475 (2007/10/02)
Thiiranes add to imines and oximes to give thiazolidines.The addition of asymmetrical thiiranes is regioselective.The reaction of derivatives of asymmetrical carbonyl compounds with methylthiirane leads to mixtures of cis and trans stereoisomers of thiazo
