82606-64-2Relevant academic research and scientific papers
Studies in the Cycloheptane Series. Part - XXXI: Friedel-Crafts Reaction of the Anhydride of αα-Dimethylglutaric Acid with Different Aromatic Hydrocarbons and Synthesis of 1,1-Dimethyl-3,4-benzo/substituted benzocycloheptanes and 1,1-Dimethylthienocycloheptane
Gautam, R. K.,Kannan, S.,Saharia, G. S.
, p. 378 - 379 (2007/10/02)
The anhydride of αα-dimethylglutaric acid on condensation with benzene, toluene, isomeric xylenes, chlorobenzene, anisole, tetralin, naphthalene and thiophene under F.C. conditions gives the respective αα-dimethyl-γ-aroyl-n-butyric acids which on Clemmensen reduction yield δ-aryl-n-valeric acids.These on cyclisation with PPA furnish III and IV (X=O) which on Clemmensen reduction give the respective hydrocarbons (III and IV: X=H2).
