82614-88-8

Basic information

• Product Name: S-1-(4-Methylbenzenesulfonate)-1,3-Butanediol
• Synonyms: S-1-(4-Methylbenzenesulfonate)-1,3-Butanediol;(S)-1-(4-Methylbenzenesulfonate)-1,3-butanediol,99%e.e.
• CAS NO: 82614-88-8
• Molecular Formula: C₁₁H₁₆O₄S
• Molecular Weight: 244.30734
• Mol File: 82614-88-8.mol
• Article Data: 27

Chemical Properties

• Appearance: /
• CAS DataBase Reference: S-1-(4-Methylbenzenesulfonate)-1,3-Butanediol(CAS DataBase Reference)
• NIST Chemistry Reference: S-1-(4-Methylbenzenesulfonate)-1,3-Butanediol(82614-88-8)
• EPA Substance Registry System: S-1-(4-Methylbenzenesulfonate)-1,3-Butanediol(82614-88-8)

Safety Data

• Hazardous Substances Data: 82614-88-8(Hazardous Substances Data)

Upstream product

• 108-05-4 vinyl acetate 
• 59744-08-0 toluene-4-sulfonic acid 3-hydroxybutyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 24621-61-2 1,3-butanediol 
• 77681-08-4 Toluene-4-sulfonic acid (S)-3-(1-ethoxy-ethoxy)-butyl ester 

Downstream Products

• 88980-13-6 (S)-hept-6-en-2-ol 
• 110920-29-1 (S)-1-(phenylthio)-3-butanol 
• 148518-96-1 (S)-3-(tert-butyldimethylsilyloxy)butyl 4-methylbenzenesulfonate 
• 946132-10-1 (3S)-1-p-toluenesulfonyloxy-3-triethylsilyloxy-butane 
• 912347-15-0 (S)-3-triisopropylsilanyloxybutyl toluene-4-sulphonate 
• 847346-81-0 (S)-4-(2-phenoxy-4-trifluoromethyl-phenoxy)-butan-2-ol 
• 847346-65-0 (S)-3-[4-(3-hydroxy-butoxy)-2-methyl-phenyl]-propionic acid methyl ester 
• 610318-99-5 (S)-[3-(3-hydroxy-butoxy)-phenyl]-acetic acid methyl ester 
• 610319-07-8 (S)-4-[N-(2,2-diphenylethyl)-amino]-butan-2-ol 
• 609772-05-6 (S)-4-[N-(2,2-diphenylethyl)-N-(2-chloro-3-(trifluoromethyl)benzyl)amino]-butan-2-ol 

Relevant articles and documents

Design and synthesis of a novel class of dual PPARγ/δ agonists

The design and synthesis of dual PPAR γ/δ agonist (R)-3-{2-ethyl-4-[3-(4-ethyl-2-pyridin-2-yl-phenoxy)-butoxy]-phenyl}propionic acid is described. This compound dose-dependently lowered plasma glucose in hyperglycemic male Zucker diabetic fatty (ZDF) rats

Small-molecule anti-HIV-1 agents based on HIV-1 capsid proteins

The capsid of human immunodeficiency virus type 1 (HIV-1) is a shell that encloses viral RNA and is highly conserved among many strains of the virus. It forms a conical structure by assembling oligomers of capsid (CA) proteins. CA dysfunction is expected to be an important target of suppression of HIV-1 replication, and it is important to understand a new mechanism that could lead to the CA dysfunction. A drug targeting CA however, has not been developed to date. Hydrophobic interactions between two CA molecules via Trp184/Met185 in CA were recently reported to be important for stabilization of the multimeric structure of CA. In the present study, a small molecule designed by in silico screening as a dipeptide mimic of Trp184 and Met185 in the interaction site, was synthesized and its significant anti-HIV-1 activity was confirmed. Structure activity relationship (SAR) studies of its derivatives were performed and provided results that are expected to be useful in the future design and development of novel anti-HIV agents targeting CA.

2 Tyrosine kinase mediated signal transduction inhibitors

Disclosed herein are compounds of Formula (), and pharmaceutically acceptable salts thereof, wherein R, R, R, R, R, X, X, X, X, X, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.