82622-43-3

Basic information

• Product Name: 1-Benzhydryl-3-phenoxy-azetidine
• Synonyms: 1-Benzhydryl-3-phenoxy-azetidine;1-(DIPHENYLMETHYL)-3-PHENOXY-AZETIDINE
• CAS NO: 82622-43-3
• Molecular Formula: C₂₂H₂₁NO
• Molecular Weight: 315.40824
• Mol File: 82622-43-3.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Benzhydryl-3-phenoxy-azetidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzhydryl-3-phenoxy-azetidine(82622-43-3)
• EPA Substance Registry System: 1-Benzhydryl-3-phenoxy-azetidine(82622-43-3)

Safety Data

• Hazardous Substances Data: 82622-43-3(Hazardous Substances Data)

Usage

Chemical class

Azetidine class of organic compounds

Derived from

Benzhydryl and phenoxy groups

Structural feature

Four-membered ring containing nitrogen

Potential applications

Medicinal chemistry and drug discovery

Unique aspects

Structure and properties

Possible characteristics

Exhibits biological activity

Synthesis role

Serve as a precursor for the synthesis of biologically active molecules

Further research

Needed to explore potential uses and properties in various fields

Upstream product

• 33301-41-6 1-benzhydryl-3-azetidinyl methanesulfonate 
• 108-95-2 phenol 

Downstream Products

• 76263-18-8 3-phenorxyazetidine 
• 1380753-73-0 5-chloro-2-(3-phenoxyazetidin-1-yl)nicotinic acid 
• 1380753-31-0 methyl 5-chloro-2-(3-phenoxyazetidin-1-yl)nicotinate 
• 1309205-42-2 (E)-6-(3-oxo-3-(3-phenoxyazetidin-1-yl)prop-1-en-1-yl)-3,4-dihydro-1,8-naphthyridin-2(1H)-one 
• 301335-39-7 3-phenoxyazetidine hydrochloride salt 

Relevant articles and documents

PYRIDINE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS

The invention relates pyridine amide derivative of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are independently hydrogen, linear o branched (C1-C3)alkyl or joined together they form a cyclopropyl ring; R is independently selected from the group consisting of halogens and trifluoromethyl and p is 1, 2 or 3; A is C or N; E is a group of formula (B) or (C), wherein B is C(O)OH, C(O)O(C1-C3)alkyl, and C is selected from the group consisting of formula (I) m is 1,2 or 3, n is 0 or 1, W is —O—, —O(C1-C3 alkyl)-; —(C1-C3 alkyl)O—; —C(O)—; —C(═N—O(C1-C3 alkyl))-; —NH— or —NH(C1-C3alkyl)-; Ar is phenyl, optionally substituted with one or more substituents selected from the group consisting of halogen, trifluoromethyl, trifluoromethoxy, methyl, —NH(C1-C3alkyl)-; —N(C1-C3alkyl)(C1-C3alkyl)-, a from 5 to 7 membered heterocyclic ring containing one nitrogen atom which is covalently bonded to Ar and optionally containing one or two heteroatoms selected from N, O and S; and a 5- or 6-membered heteroaromatic ring containing 1 to 3 heteroatoms selected from S, O e N, such heteroaromatic ring being substituted with one or two substituents selected from the group consisting of (C1-C3)alkyl, (C3-C5)cycloalkyloxy, (C1-C3)alkylcarbonyl. The compounds of the invention could be used for manufacturing a medicament for the treatment of pathologies which require the use of an antagonist of the EP4 receptor, such as the treatment of acute and chronic pain, inflammatory pain, osteoarthritis, inflammation-associated disorder as arthritis, rheumatoid arthritis, cancer, endometriosis and migraine.

NOVEL HETEROCYCLIC ACRYLAMIDES AND THEIR USE AS PHARMACEUTICALS

The invention relates to novel heterocyclic acrylamide compounds (I), to the preparation of the compounds and intermediates used therein, to the use of the compounds as antibacterial medicaments and pharmaceutical compositions containing the compounds.

Aryloxy and aryloxyalklazetidines as antiarrhythmic and anticonvulsant agents

Methods of treating cardiac arrhythmias and convulsions in warm-blooded animas and pharmaceutical compositions therefor are disclosed. The compounds useful in the methods of treatment and compositions are represented by the formula STR1 where n is 0 to 3 and R is H, C1 -C4 alkyl or arylalkyl and Ar is phenyl or substituted phenyl.