82625-90-9

Basic information

• Product Name: 2-(2-METHOXY-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID
• Synonyms: 2-(2-METHOXYPHENYL)-1,3-THIAZOLANE-4-CARBOXYLIC ACID;2-(2-METHOXY-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID;TIMTEC-BB SBB011789
• CAS NO: 82625-90-9
• Molecular Formula: C11H13NO3S
• Molecular Weight: 239.29
• Mol File: 82625-90-9.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(2-METHOXY-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-METHOXY-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID(82625-90-9)
• EPA Substance Registry System: 2-(2-METHOXY-PHENYL)-THIAZOLIDINE-4-CARBOXYLIC ACID(82625-90-9)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 82625-90-9(Hazardous Substances Data)

Usage

Uses

2-(2-Methoxyphenyl)-1,3-thiazolane-4-carboxylic acid is used as a reactant in the preparation of N-?(mercaptoacyl)?thiazolidinecarboxylic acids for antihypertensive activity.

Upstream product

• 52-89-1 l-cysteine hydrochloride 
• 135-02-4 ortho-anisaldehyde 
• 52-90-4 L-Cysteine 

Relevant articles and documents

X-ray crystal structures and anti-breast cancer property of 3-tert -butoxycarbonyl-2-arylthiazolidine-4-carboxylic acids

Diastereomeric '2RS,4R'-2-arylthiazolidine-4-carboxylic acids (ATCAs) were synthesized and their resolution to chiraly pure N-BOC derivatives was attempted by column chromatography. The absolute stereochemistry of the resolved compounds was ascertained by X-ray single crystal structures. Further application of the synthesized compounds was studied for their in vitro anti-breast cancer activity against MCF7 cell line using DOX as a standard by MTT assay method. Cell morphology analysis was carried out by fluorescence microscopy. The compounds containing '2S' absolute configuration in thiazolidine ring and presence of 2-NO2, 2,6-Cl groups on '2R'-aryl substituent showed significant anti-breast cancer activity where some of the compounds were found to be more active than DOX in terms of induced apoptosis mode of MCF7 cell death.

The cysteine releasing pattern of some antioxidant thiazolidine-4-carboxylic acids

Oxidative stress that corresponds to a significant increase in free radical concentration in cells can cause considerable damage to crucial biological macromolecules if not prevented by cellular defense mechanisms. The low-molecular-weight thiol glutathio

Synthesis, characterization and antibacterial activities of N-tert-butoxycarbonyl-thiazolidine carboxylic acid

A possible mechanism of dynamic kinetic resolution by the formation of N-tert-butoxycarbonyl-thiazolidine carboxylic acid was proposed and validated by a quantitative density functional theoretical calculation according to Curtin-Hammett principle. Such a