82632-39-1

Upstream product

• 100-42-5 styrene 
• 84459-33-6 2-bromo-4-chlorobenzaldehyde 

Downstream Products

• 82632-49-3 7-chloro-2-methyl-3-phenylisoquinolin-1(2H)-one 
• 120347-64-0 5-chloro-2-(N-t-methyliminomethyl)-trans-stilbene 
• 82632-44-8 [1-[4-Chloro-2-((E)-styryl)-phenyl]-meth-(E)-ylidene]-methyl-amine 

Relevant academic research and scientific papers

Rhodium-catalyzed intramolecular hydroacylation of 1,2-disubstituted alkenes for the synthesis of 2-substituted indanones

The intramolecular hydroacylation of 1,2-disubstituted alkenes was considered to be a challenging task due to the side reactions resulted from the lack of additional substituent at 1-position and the low activity caused by the steric hindrance of substituent at 2-position, and an asymmetric version has not been considered possible due to problems associated with the racemization of the products. We have partially solved these problems. Catalyzed by an activated diphosphine-Rh complex and reacted in a selected dihalogenated solvent, the intramolecular hydroacylation of o-(2-arylvinyl)benzaldehydes provided the corresponding 2-aryl-1-indanones in high yields, and its asymmetric variant using o-(2-alkylvinyl)benzaldehydes afforded chiral 2-alkyl-1-indanones in high yields and with moderate enantioselectivities.