82632-51-7Relevant articles and documents
Palladium-Catalyzed Synthesis of Isoquinolinones via Sequential Cyclization and N-O Bond Cleavage of N -Methoxy- o -alkynylbenzamides
Jithunsa, Manita,Ueda, Masafumi,Aoi, Naoki,Sugita, Shoichi,Miyoshi, Tetsuya,Miyata, Okiko
, p. 475 - 478 (2013/03/29)
A palladium-catalyzed controlled 6-endo-dig cyclization process has been developed for the chemoselective synthesis of isoquinolin-1-ones from N-alkoxy-o-alkynylbenzamides. The mechanism and scope of the reaction have also been investigated. Deuterium-labeling studies were used to confirm the intramolecular 1,5-hydrogen shift as a key step in the transformation. Georg Thieme Verlag Stuttgart · New York.
CYCLOPALLADATED IMINES IN SYNTHESIS: THE PREPARATION OF UNSYMMETRICAL STILBENES AND 3-ARYLISOQUINOLONES
Girling, I. R.,Widdowson, D. A.
, p. 1957 - 1960 (2007/10/02)
A series of cyclopalladated t-butylimines of aromatic aldehydes were reacted with styrene to give o-formylstilbenes in high yield.The N-methylimines of these were converted to 3-aryl-N-methyl-isoquinolones by oxidation with mercuric acetate.