82633-79-2

Usage

Uses

Used in Industrial Applications:
2-Methyl-4,5-trimethylene-4-isothiazolin-3-one is used as a biocide for [application reason] in various industrial applications, such as in paints, coatings, and adhesives, to prevent microbial growth and protect the products from spoilage and degradation.
Used in Personal Care Products:
2-Methyl-4,5-trimethylene-4-isothiazolin-3-one is used as a preservative in personal care products, such as cosmetics and toiletries, to ensure their safety, stability, and longevity by preventing the growth of harmful microorganisms.

Contact allergens

This biocide induced contact dermatitis in a laboratory technician, also sensitive to the other isothiazolinone BIT.

InChI:InChI=1/C7H9NOS/c1-8-7(9)5-3-2-4-6(5)10-8/h2-4H2,1H3

Upstream product

• 79-03-8 propionyl chloride 
• 82634-76-2 2-oxo-cyclopentanecarboxylic acid methylamide 

Relevant academic research and scientific papers

Synergistic biocide composition

A biocide composition is provided as an addition to substances that can be infected by harmful microorganisms, in which the biocide composition has at least two active biocidal substances, one of which is 2-methylisothiazolin-3-one. The composition is characterized in that it contains 1,2-benzisothiazolin-3-one, compositions containing 5-chloro-2-methylisothiazolin-3-one being excluded. In comparison with its individual components, the composition of the invention has a synergistic biocidal activity.

Process for the preparation of isothiazolinones

Compounds of the general formula STR1 are cyclised to the corresponding isothiazolinone using a carbonyl halide of the formula RCOX where R is halogen or alkyl and X is halogen. R3 and R4 are preferably such as to form a 5 or 6 membered ring. Useful carbonyl halides are phosgene and propionyl chloride. Using acyl halides such as propionyl chloride, a mixture of the isothiazolinone and a salt of the carboxylic acid can be obtained, for example an essentially equimolar mixture of 2-methyl-4,5-trimethyl-4-isothiazolin-3-one and sodium propionate

Sulfur containing diamides and antimicrobial use

A compound of the formula STR1 in which R1 and R2 taken together, and R3 and R4 taken together, independently represent a polymethylene chain having 3 or 4 carbon atoms, or a polymethylene chain having 3 or 4 carbon atoms substituted by at least one lower alkyl radical having from 1 to 4 carbon atoms, and R5 to R8 are independently hydrogen, hydrocarbyl or substituted hydrocarbyl. Typically R1 and R2 and also R3 and R4 complete a trimethylene ring, R5 and R7 are each hydrogen and R6 and R8 are alkyl such as methyl. The compounds have microbiological activity.

4,5-trimethylene-4-isothiazoline-3-ones and their use as a bactericide and fungicide agent

A 4,5-trimethylene-4-isothiazoline-3-one of the formula STR1 wherein R1 represents (i) hydrogen, (ii) alkyl having 1-12 carbon atoms, (iii) alkyl having 2 or 3 carbon atoms and substituted by one or two hydroxy groups, (iv) alkenyl having 3 to