82635-66-3

Upstream product

• 656-32-6 N-(2-fluorophenyl)thiourea 
• 73999-10-7 N-(o-fluorophenyl)-N'-benzoyl-thiourea 
• 348-54-9 2-Fluoroaniline 
• 74-88-4 methyl iodide 

Downstream Products

• 82635-87-8 2-[3-(2-Fluoro-phenyl)-2-methyl-isothioureidomethylene]-malonic acid diethyl ester 
• 82636-12-2 1-(2-Fluoro-phenyl)-2-methylsulfanyl-6-oxo-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 89069-42-1 3-(2-fluorophenyl)-2-methylthio-6-phenyl-4(3H)-pyrimidinones 
• 89089-61-2 3-(2-fluorophenyl)-6-methyl-2-methylthio-4(3H)-pyrimidinone 
• 89069-19-2 3-(2-fluorophenyl)-2-methylthio-4(3H)-pyrimidinone 

Relevant academic research and scientific papers

GUANIDINE DERIVATIVES USEFUL IN THERAPY

Guanidine derivatives of formulanidine derivatives of formula I, wherein R8 represents hydrogen, halogen, alkyl C1 to 6, nitro, trifluoromethyl, thioalkyl C1 to 6, hydroxy, alkoxy C1 to 6, or a group selected from NR4R5, -O(CH2)pQ, -(CH2)mOQ, -(CH2)mNR1R2, -O(CH2)mNR1R2, -NHCO(CH2)mNH(CH2)nQ or -(CH2)pCONR1R2, or R8 represents the group A-CO-B; R9 represents hydrogen, halogen, alkyl C1 to 6, nitro or trifluoromethyl; and R1, R2, R4, R5, n, m, p, Q, A, B, and W are as defined in the specification, are described together with processes for their manufacture and compositions containing them. Compounds of formula I are useful in therapy

Synthesis & Pharmacological Evaluation of Ethyl 3-Substituted-phenyl-2-methylmercapto/ phenyl/ methyl-4(3H)-pyrimidone-5-carboxylates

A number of ethyl 3-substituted-phenyl-2-methylmercapto/ phenyl/ methyl-4(3H)-pyrimidone-5-carboxylates (V) have been prepared by the reaction of amidines (III) with diethyl ethoxymethylenemalonate.In order to confirm the structure (V), ethyl 3-(2'-methylphenyl)-2-methylmercapto-4(3H)pyrimidone-5-carboxylate (103) has been transformed into the earlier synthesised 3-(2'-methylphenyl)-2-methylmercapto-4(3H)-pyrimidone (115) by decarboxylation of 3-(2'-methylphenyl)-2-methylmercapto-4(3H)-pyrimidone-5-carboxylic acid (114), obtained by the alkaline hydrolysis of 103.Someof these compounds have shown antiinflammatory, diuretic and antipassive cutaneous anaphylaxis activities.