73999-10-7

Basic information

• Product Name: N-(o-fluorophenyl)-N'-benzoyl-thiourea
• Synonyms: N-(o-fluorophenyl)-N'-benzoyl-thiourea
• CAS NO: 73999-10-7
• Molecular Weight: 274.319
• Mol File: 73999-10-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(o-fluorophenyl)-N'-benzoyl-thiourea(CAS DataBase Reference)
• NIST Chemistry Reference: N-(o-fluorophenyl)-N'-benzoyl-thiourea(73999-10-7)
• EPA Substance Registry System: N-(o-fluorophenyl)-N'-benzoyl-thiourea(73999-10-7)

Safety Data

• Hazardous Substances Data: 73999-10-7(Hazardous Substances Data)

Upstream product

• 348-54-9 2-Fluoroaniline 
• 1147550-11-5 ammonium thiocyanate 
• 98-88-4 benzoyl chloride 
• 532-55-8 Benzoyl isothiocyanate 

Downstream Products

• 656-32-6 N-(2-fluorophenyl)thiourea 
• 82636-12-2 1-(2-Fluoro-phenyl)-2-methylsulfanyl-6-oxo-1,6-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 82635-66-3 N-(2-fluorophenyl)-S-methylisothiourea 
• 82635-87-8 2-[3-(2-Fluoro-phenyl)-2-methyl-isothioureidomethylene]-malonic acid diethyl ester 

Relevant articles and documents

Structure-activity relationships of 2-aminothiazoles effective against Mycobacterium tuberculosis

A series of 2-aminothiazoles was synthesized based on a HTS scaffold from a whole-cell screen against Mycobacterium tuberculosis (Mtb). The SAR shows the central thiazole moiety and the 2-pyridyl moiety at C-4 of the thiazole are intolerant to modification. However, the N-2 position of the aminothiazole exhibits high flexibility and we successfully improved the antitubercular activity of the initial hit by more than 128-fold through introduction of substituted benzoyl groups at this position. N-(3-Chlorobenzoyl)-4-(2-pyridinyl) -1,3-thiazol-2-amine (55) emerged as one of the most promising analogues with a MIC of 0.024 μM or 0.008 μg/mL in 7H9 media and therapeutic index of nearly ～300. However, 55 is rapidly metabolized by human liver microsomes (t1/2 = 28 min) with metabolism occurring at the invariant aminothiazole moiety and Mtb develops spontaneous low-level resistance with a frequency of ～10-5.

Synthesis and Cytotoxicity in Vitro of N-Aryl-4-(Tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amine

A series of novel N-aryl-4-(tert-butyl)-5-(1H-1,2,4-triazol-1-yl)thiazol-2-amines were synthesized in a green way. H2O2-NaBr Brominating circulatory system was used in the synthesis of the key intermediate in a mild condition. All of the target compounds were confirmed by1H NMR and elemental analysis and tested for their cytotoxicity against two different human cancer cell lines. The cytotoxicity assay revealed that some of the title compounds showed moderate to strong cytotoxic activities. Compound 2i was the most potent compound with the IC50 values of 9 μMagainst Hela cells and 15 μMagainst Bel-7402 cells, respectively.