82635-68-5

Upstream product

• 1544-68-9 4-fluorophenyl isothiocyanate 
• 459-05-2 (4-fluoro-phenyl)-thiourea 
• 74-88-4 methyl iodide 
• 371-40-4 4-fluoroaniline 
• 399-07-5 N-((4-fluorophenyl)carbamothioyl)benzamide 

Downstream Products

• 89069-21-6 3-(4-fluorophenyl)-2-methylthio-4(3H)-pyrimidinone 
• 89069-44-3 3-(4-fluorophenyl)-2-methylthio-6-phenyl-4(3H)-pyrimidinones 
• 213739-37-8 C₂₆H₄₁FN₄O₆ 
• 213739-30-1 N-p-fluorophenyl-N'-t-butyloxycarbonyl-S-methylisothiourea 
• 82635-88-9 2-[3-(4-Fluoro-phenyl)-2-methyl-isothioureidomethylene]-malonic acid diethyl ester 

Relevant academic research and scientific papers

A NO donor type he Augmentin derivatives, preparation method and application (by machine translation)

The invention provides a having the general formula (I) as shown in the structural formula of the compound, the compound has better NO release of the active, with better prospect of application, can be used for anti-inflammatory, anti-thrombotic, anti-platelet activity, reducing cholesterol and triglyceride levels and/or improve the high density lipoprotein levels, treatment of peripheral ischemia, diabetic vascular complications in or atherosclerosis. The invention also provides a method for preparing said compound. (by machine translation)

A General Procedure for Synthesis of NG-Alkyl, and NG-Aryl-L-Arginines as Potential Nitric Oxide Synthase Inhibitors

A general procedure for the synthesis of NG-alkyl, and NG-aryl-L-arginines with relatively high overall yield is reported. The key step involved the coupling of protected L-ornithine 4 with isothiourea 7 to give the fully protected NG-aryl-L-arginine derivative 8. Subsequent deprotection of 8 in acidic condition provided the final target compound 9 with an overall yield of more than 80%.

Synthesis & Pharmacological Evaluation of Ethyl 3-Substituted-phenyl-2-methylmercapto/ phenyl/ methyl-4(3H)-pyrimidone-5-carboxylates

A number of ethyl 3-substituted-phenyl-2-methylmercapto/ phenyl/ methyl-4(3H)-pyrimidone-5-carboxylates (V) have been prepared by the reaction of amidines (III) with diethyl ethoxymethylenemalonate.In order to confirm the structure (V), ethyl 3-(2'-methylphenyl)-2-methylmercapto-4(3H)pyrimidone-5-carboxylate (103) has been transformed into the earlier synthesised 3-(2'-methylphenyl)-2-methylmercapto-4(3H)-pyrimidone (115) by decarboxylation of 3-(2'-methylphenyl)-2-methylmercapto-4(3H)-pyrimidone-5-carboxylic acid (114), obtained by the alkaline hydrolysis of 103.Someof these compounds have shown antiinflammatory, diuretic and antipassive cutaneous anaphylaxis activities.