82636-14-4Relevant academic research and scientific papers
PYRIDONE COMPOUNDS AND METHODS OF USE IN THE MODULATION OF A PROTEIN KINASE
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Paragraph 01166, (2021/04/02)
The present disclosure relates generally to compounds and pharmaceutical compositions suitable as modulators of protein kinases, and methods for their use in treating disorders mediated, at least in part by, protein kinases.
C-Met kinase inhibitor 3-(4-fluorophenyl)pyrimidone-5-formic acid amide derivative, preparation method and application
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Paragraph 0131; 0132; 0133, (2017/08/28)
The invention relates to a series novel pyrimidine derivative serving as c-Met tyrosine kinase inhibitors and a preparation method thereof and application of the derivative in treatment of increase of abnormal cells such as cancers. By means of pharmacology activity testing, a compound of a formula (I) and pharmaceutically acceptable salts have the good antineoplastic activity and can be used for treating or preventing various cancers related to the c-Met inhibitors.
Synthesis & Pharmacological Evaluation of Ethyl 3-Substituted-phenyl-2-methylmercapto/ phenyl/ methyl-4(3H)-pyrimidone-5-carboxylates
Gupta, K. A.,Saxena, Anil K.,Jain, Padam C.
, p. 228 - 233 (2007/10/02)
A number of ethyl 3-substituted-phenyl-2-methylmercapto/ phenyl/ methyl-4(3H)-pyrimidone-5-carboxylates (V) have been prepared by the reaction of amidines (III) with diethyl ethoxymethylenemalonate.In order to confirm the structure (V), ethyl 3-(2'-methylphenyl)-2-methylmercapto-4(3H)pyrimidone-5-carboxylate (103) has been transformed into the earlier synthesised 3-(2'-methylphenyl)-2-methylmercapto-4(3H)-pyrimidone (115) by decarboxylation of 3-(2'-methylphenyl)-2-methylmercapto-4(3H)-pyrimidone-5-carboxylic acid (114), obtained by the alkaline hydrolysis of 103.Someof these compounds have shown antiinflammatory, diuretic and antipassive cutaneous anaphylaxis activities.
