82645-24-7

Usage

Type of compound

bisphenol

Usage

production of epoxy resins, cross-linking agent in polymer chemistry, building block in synthesis of organic compounds and materials

Structure

two ethylene glycol side chains connected to an ethane backbone, each containing a formylphenoxy group

Hazardous nature

potentially hazardous chemical, should be handled with care due to potential health and environmental effects

Upstream product

• 5414-19-7 1,1'-oxybis(2-bromo-ethane) 
• 90-02-8 salicylaldehyde 
• 7460-82-4 diethylene glycol ditosylate 
• 111-44-4 3-oxa-1,5-dichloropentane 
• 3116-83-4 sodium salicylate 
• 89-95-2 2-methyl-benzyl alcohol 
• 90-01-7 salicylic alcohol 

Downstream Products

• 1223512-93-3 1,5-bis[2-(3-phenyl-3-oxoprop-1-en-1-yl)phenoxy]-3-oxa-pentane 
• 1258542-44-7 C₄₅H₄₈N₁₀O₁₂ 
• 1408218-68-7 N,N'-(2,2'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(2,1-phenylene))bis(methan-1-yl-1-ylidene)bis(3,5-diphenyl-4H-1,2,4-triazol-4-amine) 
• 1448243-91-1 C₂₄H₁₈N₄O₃ 
• 1429339-09-2 C₁₈H₂₂O₅ 
• 1629992-88-6 C₂₄H₂₆O₅ 
• 1592962-76-9 C₁₈H₂₀Cl₂O₃ 

Relevant academic research and scientific papers

Spectroscopic and electrochemical studies of transition metal complexes with N,N′-bis(2-aminothiophenol)-1,7-bis(2-formylphenyl)-1,4,7- trioxaheptane and structure effects on extractability of ligand towards some divalent cations

La(III), Cu(II), Ni(II), and Zn(II) metal complexes with a novel quadridentate Schiff base derived from 1,7-bis(2-formylphenyl)-1,4,7- trioxaheptane and 2-aminothiophenol were synthesized and characterized by microanalytical data, elemental analysis, magn

Formation of a four-bladed waterwheel-type chloro-bridged dicopper(ii) complex with dithiamacrocycle: Via double exo-coordination

A combination of O3S2-macrocycles incorporating different sulfur-to-sulfur separations (S-(CH2)n-S, L1: N = 2, L2: N = 3) and copper(ii) nitrate afforded new types of both monocopper(ii) an

Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties

A series of novel tetracoumarin derivatives (3a-f) were prepared using the reaction of ether functionalized dibenzaldehyde with 4-hydroxycoumarin in the presence of sodium acetate. The structure of compounds was validated by IR, NMR, and CHN analyzes. Antimicrobial (antibacterial and antifungal) activity was studied on the basis of the minimum bactericidal concentration, minimum inhibitory concentration and inhibitory zone diameter. Favorable biological activity was found in compound 3f.

DIMER COMPOUNDS, AND USE IN BINDING TOXIC REPEATS OF RNA

Provided herein are compounds and methods for modulating abnormal repeat expansions of gene sequences. More particularly, provided are dimeric inhibitors of RNA and the uses of such inhibitors in regulating nucleotide repeat expansions, e.g., to treat Myotonic Dystrophy Type 1 (DM1), Myotonic Dystrophy Type 2 (DM2), Fuchs dystrophy, Huntington Disease, Amyotrophic Lateral Sclerosis, or Frontotemporal Dementia.

Synthesis of novel N,O-macrocyclic ligands, functionalized by phosphine oxide groups

[Figure not available: see fulltext.] As a result of the implementation of two approaches, the Pudovik reaction (the reaction of macrocyclic azomethines with secondary phosphine oxides) and the Kabachnik–Fields reaction (three-component one-pot process involving dialdehydes, diamines, and secondary phosphine oxides), novel N,O-containing macrocyclic ligands with phosphine oxide groups were first obtained. The synthesized macrocycles are a kind of α-aminophosphoryl compounds that can be used in the synthesis of supramolecular systems.

Exploitation of Intramolecular Glaser-Eglinton-Hay Macrocyclization for the Synthesis of New Classes of Optically Active Aza-Oxo-Thia Polyether Macrocycles from Amino Alcohol Building Blocks

We report an intramolecular Glaser-Eglinton-Hay coupling as an unprecedented route for assembling optically active aza-oxo polyether macrocycles containing a 1,3-diyne unit from enantiopure amino alcohol building blocks and suitable linkers. Furthermore, the conversion of the 1,3-diyne unit of the aza-oxo polyether macrocycles into a thiophene ring led to the assembly of new classes of optically active aza-oxa-thia (heterotopic) polyether macrocycle analogues of classical 18-C-6 and 18-C-5 systems.

An entry into new classes of optically active aza-oxo polyether macrocycles via the ring closing metathesis-based macrocyclization

We report the application of ring closing metathesis-based macrocyclization route for synthesizing 22–36 membered optically active aza-oxo crowns/polyether macrocycles. While the RCM-based synthesis of polyether macrocycles was well explored in the literature, the synthesis of optically active polyether macrocycles was not explored via the RCM reaction. Accordingly, the present method reveals an efficient assembling of a library of new classes of optically active aza-oxo polyether macrocycles from optically active RCM precursors, which were assembled from easily available linkers, chiral α-methylbenzylamine and amino alcohol building blocks under simple reaction conditions.

Ring-closing metathesis reaction-based synthesis of new classes of polyether macrocyclic systems

Ring closing metathesis (RCM) reactions of suitable substrates having terminal olefins, which are assembled from various linkers and hydroxy benzaldehydes and syntheses of a wide range of 16-30 membered, new crown ether-type polyether, aza-polyether, bis aza-polyether macrocycles and dilactone moiety embedded polyether macrocycles (macrolides) are reported. After the ring-closure reaction, installation of different functional groups and functional group modification on the periphery of the synthesized polyether/crown ether macrocycles obtained in the RCM reactions are accomplished using the epoxidation, oxidation and catalytic hydrogenation-based synthetic transformations. Along this line, the syntheses of a variety of polyether macrocycles possessing epoxide or α-hydroxy ketone or 1,2-diol functionalities at the periphery have been shown. Furthermore, the synthesized α-hydroxy ketone functionality installed polyether macrocycles were subjected to the allylation and Reformatsky type reactions to obtain homoallyl alcohol moiety-based and lactone ring-appended polyether macrocycles.

Efficient synthesis of novel benzylidene barbituric and thiobarbituric acid derivatives containing ethyleneglycol spacers

Knoevenagel condensation reaction of ethylene glycol-based aromatic aldehyde with barbituric acid derivatives in ethanol produced novel benzylidene barbituric and thiobarbituric acid derivatives which contain good yields of ethylene glycol spacers. Structures of the products were deduced from their IR, 1H-NMR, and 13C-NMR spectroscopy and mass spectra.

Application of Bayer-Villiger reaction to the synthesis of dibenzo-18-crown-6, dibenzo-21-crown-7 and dihydroxydibenzo-18-crown-6

Dibenzo-18-crown-6, dibenzo-21-crown-7 and dihydroxy dibenzo-18-crown-6 were synthesized by Bayer-Villiger oxidation strategy. Dibenzo-18-crown-6 and dibenzo-21-crown-7 could be synthesized through a three-step protocol starting from salicylaldehyde. Salicylaldehyde was reacted with bis-(2-chloroethyl)ether using K2CO3 in acetonitrile to link the two phenolic groups with the oxyethylene bridge followed by conversion of the formyl group to the hydroxy group via a Baeyer-Villiger reaction and finally linking the two phenolic group with appropriate oxyethylene bridge. The two target crown ethers were obtained in overall yield, 24% and 30%, respectively. This method has a great potential for synthesis of symmetrical as well as unsymmetrical dibenzo crowns with varying oxyethylene bridges. Baeyer-Villiger oxidation could be used to prepare dihydroxy derivative of dibenzo-18-crown-6 through acetylation of dibenzo-18-crown-6 followed by Baeyer-Villiger oxidation. The Baeyer-Villiger oxidation could be substantially accelerated using trifluoroacetic acid.