82645-25-8Relevant academic research and scientific papers
Synthesis and spectral studies of macrocyclic Pb(II), Zn(II) and La(III) complexes by template reaction of 1,4-bis(3-aminopropoxy)butane with metal nitrate and salicylaldehyde derivatives
Ilhan, Salih
, p. 1 - 4 (2010)
Six new macrocyclic complexes are synthesised by template reaction of 1,4-bis(3-aminopropoxy)butane with metal nitrate and 1,7-bis(2-formylphenyl)-1, 4,7-trioxaheptane or 1,10-bis(2-formylphenyl)-1,4,7,10-tetraoxadecane and their structures are proposed on the basis of elemental analysis, FT-IR, UV-Vis, molar conductivity measurements, 1H NMR and mass spectra. The complexes are 1:2 electrolytes for Pb(II),Zn(II) complexes and 1:3 electrolytes for La(III) as shown by their molar conductivities (Am) in DMSO at 1003 mol L-1. The confi gurations of La(III) and Zn(II) complexes are proposed to probably octahedral.
Synthesis and characterization of novel biological tetracoumarin derivatives bearing ether moieties
Behzadi, Soheila Asadpour,Sheikhhosseini, Enayatollah,Ahmadi, Sayed Ali,Ghazanfari, Dadkhoda,Akhgar, Mohammadreza
, p. 60 - 67 (2020/06/08)
A series of novel tetracoumarin derivatives (3a-f) were prepared using the reaction of ether functionalized dibenzaldehyde with 4-hydroxycoumarin in the presence of sodium acetate. The structure of compounds was validated by IR, NMR, and CHN analyzes. Antimicrobial (antibacterial and antifungal) activity was studied on the basis of the minimum bactericidal concentration, minimum inhibitory concentration and inhibitory zone diameter. Favorable biological activity was found in compound 3f.
DIMER COMPOUNDS, AND USE IN BINDING TOXIC REPEATS OF RNA
-
, (2020/07/16)
Provided herein are compounds and methods for modulating abnormal repeat expansions of gene sequences. More particularly, provided are dimeric inhibitors of RNA and the uses of such inhibitors in regulating nucleotide repeat expansions, e.g., to treat Myotonic Dystrophy Type 1 (DM1), Myotonic Dystrophy Type 2 (DM2), Fuchs dystrophy, Huntington Disease, Amyotrophic Lateral Sclerosis, or Frontotemporal Dementia.
Exploitation of Intramolecular Glaser-Eglinton-Hay Macrocyclization for the Synthesis of New Classes of Optically Active Aza-Oxo-Thia Polyether Macrocycles from Amino Alcohol Building Blocks
Babu, Srinivasarao Arulananda
supporting information, p. 253 - 259 (2017/01/25)
We report an intramolecular Glaser-Eglinton-Hay coupling as an unprecedented route for assembling optically active aza-oxo polyether macrocycles containing a 1,3-diyne unit from enantiopure amino alcohol building blocks and suitable linkers. Furthermore, the conversion of the 1,3-diyne unit of the aza-oxo polyether macrocycles into a thiophene ring led to the assembly of new classes of optically active aza-oxa-thia (heterotopic) polyether macrocycle analogues of classical 18-C-6 and 18-C-5 systems.
An entry into new classes of optically active aza-oxo polyether macrocycles via the ring closing metathesis-based macrocyclization
Naveen,Babu, Srinivasarao Arulananda
supporting information, p. 5690 - 5694 (2016/11/28)
We report the application of ring closing metathesis-based macrocyclization route for synthesizing 22–36 membered optically active aza-oxo crowns/polyether macrocycles. While the RCM-based synthesis of polyether macrocycles was well explored in the literature, the synthesis of optically active polyether macrocycles was not explored via the RCM reaction. Accordingly, the present method reveals an efficient assembling of a library of new classes of optically active aza-oxo polyether macrocycles from optically active RCM precursors, which were assembled from easily available linkers, chiral α-methylbenzylamine and amino alcohol building blocks under simple reaction conditions.
Efficient synthesis of novel benzylidene barbituric and thiobarbituric acid derivatives containing ethyleneglycol spacers
Faryabi, Malihe,Sheikhhosseini, Enayatollah
, p. 427 - 432 (2015/02/05)
Knoevenagel condensation reaction of ethylene glycol-based aromatic aldehyde with barbituric acid derivatives in ethanol produced novel benzylidene barbituric and thiobarbituric acid derivatives which contain good yields of ethylene glycol spacers. Structures of the products were deduced from their IR, 1H-NMR, and 13C-NMR spectroscopy and mass spectra.
Ring-closing metathesis reaction-based synthesis of new classes of polyether macrocyclic systems
Naveen,Babu, Srinivasarao Arulananda
supporting information, p. 7758 - 7781 (2015/09/08)
Ring closing metathesis (RCM) reactions of suitable substrates having terminal olefins, which are assembled from various linkers and hydroxy benzaldehydes and syntheses of a wide range of 16-30 membered, new crown ether-type polyether, aza-polyether, bis aza-polyether macrocycles and dilactone moiety embedded polyether macrocycles (macrolides) are reported. After the ring-closure reaction, installation of different functional groups and functional group modification on the periphery of the synthesized polyether/crown ether macrocycles obtained in the RCM reactions are accomplished using the epoxidation, oxidation and catalytic hydrogenation-based synthetic transformations. Along this line, the syntheses of a variety of polyether macrocycles possessing epoxide or α-hydroxy ketone or 1,2-diol functionalities at the periphery have been shown. Furthermore, the synthesized α-hydroxy ketone functionality installed polyether macrocycles were subjected to the allylation and Reformatsky type reactions to obtain homoallyl alcohol moiety-based and lactone ring-appended polyether macrocycles.
The effect of the molecular structures of dicyanomethylene compounds on their supramolecular assembly, photophysical and electrochemical properties
Matos, Catiucia R. M. O.,Miranda, Fabio S.,Carneiro, Jose W. De M.,Pinheiro, Carlos B.,Ronconi, Celia M.
, p. 13013 - 13023 (2013/08/23)
Two series of flexible dicyanomethylene compounds, specifically, class 1 and class 2 compounds, have been designed and synthesised. In class 1 compounds, the dicyanomethylene groups are separated by glycol chain spacers of different lengths, whereas, in class 2 compounds, the spacers are alkyl linkers of different lengths. The notion underlying the design of these compounds is that in class 1 molecules, the spacers contain donor oxygen atoms that could not only form hydrogen bonds during the course of crystal packing but also promote withdrawing effects that modify the photophysical and electrochemical properties of these molecules in solution; in contrast, these effects would be absent for class 2 molecules. However, this study revealed that, with respect to crystal packing, the size of the spacers and their even and odd numbers of atoms are more important than their chemical nature. All of the synthesised compounds exhibited blue emission in the solid state and in CH2Cl2 solutions. The photophysical and electrochemical properties of these compounds in solution were not significantly affected by the type and length of the spacer that was used in each molecule. In the solid state, however, the compound with the shortest spacer showed the highest Stokes shift. The electronic transitions for the synthesized compounds in solution were explained by density functional theory and time-dependent density functional theory calculations, which indicated that the methylene moieties control the properties of both classes of compounds and that the spacers do not conjugate with the end groups. These two series of flexible dicyanomethylene compounds could be utilised as molecular building blocks for the development of new solids with novel properties. the Owner Societies 2013.
Synthesis, extraction and antibacterial studies of some new bis-1,2,4-triazole derivatives part II
Guemruekcueoglu, Nurhan,Ugras, Serpil,Ugras, Halil Ibrahim,Cakir, Uemit
scheme or table, p. 359 - 367 (2012/10/07)
The treatment of 4-amino-3,5-diphenyl-4H-1,2,4-triazole 3 with various bis-aldehydes resulted in the formation of bis-4-arylidenamino-3,5-diphenyl-4H- 1,2,4-triazoles (4a-d) derivatives. NaBH4 reduction of 4-arylidenamino derivatives of 1,2,4-t
Studies on the synthesis of ether-, substituted alkyl-, or aryl-linked C-disaccharide derivatives
Nagarajan, Subbiah,Jeganathan Shanmugam,Mohan Das, Thangamuthu
, p. 722 - 727 (2011/06/19)
A series of ether-, substituted alkyl-, or aryl-linked disaccharide derivatives have been synthesized in relatively good yield and characterized using different spectral techniques including single-crystal X-ray diffraction (XRD). β-Anomeric forms of sugar moiety in these derivatives were identified from 1H NMR studies. The existence of inter- and intramolecular hydrogen bonding interactions were identified from single-crystal XRD studies.
