82649-92-1Relevant academic research and scientific papers
Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase
Garbaccio, Robert M.,Huang, Shaei,Tasber, Edward S.,Fraley, Mark E.,Yan, Youwei,Munshi, Sanjeev,Ikuta, Mari,Kuo, Lawrence,Kreatsoulas, Constanine,Stirdivant, Steve,Drakas, Bob,Rickert, Keith,Walsh, Eileen S.,Hamilton, Kelly A.,Buser, Carolyn A.,Hardwick, James,Mao, Xianzhi,Beck, Stephen C.,Abrams, Marc T.,Tao, Weikang,Lobell, Rob,Sepp-Lorenzino, Laura,Hartman, George D.
, p. 6280 - 6285 (2008/03/13)
From HTS lead 1, a novel benzoisoquinolinone class of ATP-competitive Chk1 inhibitors was devised and synthesized via a photochemical route. Using X-ray crystallography as a guide, potency was rapidly enhanced through the installation of a tethered basic
Pyridyl-substituted Cyclobutanes via Photodimerisation of Azastilbenes
Horner, Michael,Huenig, Siegfried
, p. 1183 - 1210 (2007/10/02)
Mono- and diazastilbenes A1 - A9 as well as their mono- and dihydro- or -alkyl quaternary salts are irradiated (UV).Mono salts are smoothly converted into cyclobutanes C in crystalline state and/or in solution.The free bases A or their bis salts, reacting in solution only, from partly or exclusively different products.Their structures together with the constitutions and configurations of the cyclobutanes A are elucidated.Results from the literature are partly confirmed and partly corrected.
