38382-00-2Relevant academic research and scientific papers
A simple pyridine-based colorimetric chemosensor for highly sensitive and selective mercury(II) detection with the naked eye
Pan, Jian-Ting,Zhu, Fei,Kong, Lin,Yang, Long-Mei,Tao, Xu-Tang,Tian, Yu-Peng,Lu, Hong-Bo,Yang, Jia-Xiang
, p. 527 - 535 (2015)
Two easily-prepared pyridine-based derivatives of (Z)-2-(4-amino-phenyl)-3-(pyridine-4-yl)acrylonitrile (I) and (Z)-2-phenyl-3-(pyridin-4-yl)acrylonitrile (II ) were designed, synthesised and characterised. Due to the formation of a complex with Hg2+
Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase
Garbaccio, Robert M.,Huang, Shaei,Tasber, Edward S.,Fraley, Mark E.,Yan, Youwei,Munshi, Sanjeev,Ikuta, Mari,Kuo, Lawrence,Kreatsoulas, Constanine,Stirdivant, Steve,Drakas, Bob,Rickert, Keith,Walsh, Eileen S.,Hamilton, Kelly A.,Buser, Carolyn A.,Hardwick, James,Mao, Xianzhi,Beck, Stephen C.,Abrams, Marc T.,Tao, Weikang,Lobell, Rob,Sepp-Lorenzino, Laura,Hartman, George D.
, p. 6280 - 6285 (2007)
From HTS lead 1, a novel benzoisoquinolinone class of ATP-competitive Chk1 inhibitors was devised and synthesized via a photochemical route. Using X-ray crystallography as a guide, potency was rapidly enhanced through the installation of a tethered basic
An aqueous phase synthesis of cyano substituted styrene compound method
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Paragraph 0050; 0051, (2016/12/16)
The invention discloses a method for aqueous-phase synthesizing cyan-substituted styrene compounds. The cyan-substituted styrene compounds are synthesized by taking water as a solvent and taking benzyl cyanide and aromatic aldehyde as materials through noevenagel condensation reaction, wherein the aromatic aldehyde is selected from formula shown in the specification. According to the invention, the reaction is carried out at a room temperature; relative to other high-temperature reactions in the prior art, not only is yield improved, but also energy resources are saved, and therefore, the method is beneficial to low-carbon harmless green engineering. White spherical precipitates are generated after reaction and dehydration, and the white spherical precipitates are washed in water to neutral, and dried to obtain a target product; and besides, the method is simple in synthetic steps, easy for treatment and high in yield.
Replacement Substituent Constants for Simple Heterocycles
Robinson, Charles N.,Wiseman, Leonard J. Jr.,Slater, Carl D.
, p. 4103 - 4112 (2007/10/02)
13C nmr absorptions are reported for the β-vinylic carbon atoms in 15 series of ethylenes bearing heterocyclic substituents.The data are used to establish the best single-parameter substituent constants, ?13, for the various heterocycles as replacements for para-substituted benzenes.Also reported are replacement dual substituent constants, including ?I and the various ?R scales needed in the Taft DSP treatment and those for F and R used in the Swain-Lupton treatment.Values of ?13, F, R, ?I, and ?Ro, respectively, for the various heterocycles as replacements for para-substituted benzenes are as follows: 2-furyl, -1.01 , 0.99, -2.51, 0.65, -0.60; 2-pyrryl, -2.53, 0.52, -5.09, -0.16, -0.62; 2-thienyl, -0.79, 2.49, -3.60, 1.82, -1.08; 3-thienyl, -0.40, 1.04, -1.57, 0.59, -0.39; 2-pyridyl, 0.88, 2.09, -0.24, 1.65, -0.45; 3-pyridyl, 0.60, 0.57, 0.63, 0.35, 0.04; and 4-pyridyl, 1.18, 1.22, 1.09, 0.92, -0.01.The DSP-NLR method of analysis is explored using electron demand parameters, ε, as determined for the vinylic side chains in para-substituted styrenes.
Side-chain Nucleophilic Reactivity of Five-membered Heterocyclic Rings: Base-catalysed Reactions of Aldehydes with Phenylacetonitrile
Alberghina, Gaetano,Amato, M. Emanuela,Fisichella, Salvatore,Pisano, Danila
, p. 295 - 298 (2007/10/02)
The rates of the sodium methoxide-catalysed condensations of heteroaromatic aldehydes (Ar=C6H5, C6H4CH3-p, C6H4OCH3-p, C6H4Cl-p, 2-thienyl, 2-furyl, pyrrol-2-yl, N-methylpyrrol-2-yl, 1-naphthyl, 3-pyridyl, 4-pyridyl) with phenylacetonitrile are measured i
