82655-59-2

Upstream product

• 58676-54-3 bis(1,1-diethyl-3-benzoylthioureato) nickel(II) 
• 58328-36-2 N,N-diethyl-N'-benzoyl-thiourea 

Downstream Products

• 122195-57-7 N-(p-phenyl)-N'-(diethylaminothiocarbonyl)benzamidin 
• 130750-20-8 3-{[(Diethyl-thiocarbamoylimino)-phenyl-methyl]-amino}-benzoic acid 
• 130750-21-9 4-{[(Diethyl-thiocarbamoylimino)-phenyl-methyl]-amino}-benzoic acid 
• 90473-92-0 N-(diethylaminothiocarbonyl)-N'-monoethylbenzamidine 
• 90473-91-9 1,1-Diethyl-3-[1-(4-nitro-phenylamino)-1-phenyl-meth-(Z)-ylidene]-thiourea 
• 90473-97-5 N-(diethylaminothiocarbonyl)N',N'-diethylbenzamidine 
• 130750-22-0 2-{[(Diethyl-thiocarbamoylimino)-phenyl-methyl]-amino}-benzoic acid ethyl ester 
• 121801-50-1 N,N'-o-phenylen-bis-(N'',N''-diethyl-N'''-benzimidoyl-thioureato)nickel(II) 
• 86846-05-1 bis(1,1-diethyl-3-selenobenzoyl-thioureato)nickel(II) 
• 1354914-71-8 C₃₁H₃₂N₃PS 
• 129117-65-3 1,1-Diethyl-3-[1-methylselanyl-1-phenyl-meth-(Z)-ylidene]-thiourea 
• 129136-05-6 1,1-Diethyl-3-[1-methylsulfanyl-1-phenyl-meth-(Z)-ylidene]-thiourea 
• 130750-24-2 4-{[(Diethyl-thiocarbamoylimino)-phenyl-methyl]-amino}-benzoic acid ethyl ester 
• 69186-17-0 N-(diethylaminothiocarbonyl)-N'-phenylbenzamidine 

Relevant academic research and scientific papers

N-(AMINO-THIOCARBONYL)-BENZIMIDCHLORIDE

The reaction of nickel(II)chelates of N',N'-disubstituted N-benzoyl-thioureas with thionylchloride in a non polar solvent yields N-(amino-thiocarbonyl)-benzimide chlorides.

Thiosemicarbazones and thiadiazines derived from fluorinated benzoylthioureas: Synthesis, crystal structure and anti-Trypanosoma cruzi activity

A series of thiosemicarbazones was obtained by condensation of halogenated N-(diethylaminothiocarbonyl)benzimidoyl chlorides (3b–3h) with 4,4-dimethyl-3-thiosemicarbazide. The activity of the halogenated compounds against the parasite Trypanosoma cruzi was evaluated and compared to the previously reported activity of the corresponding non-substituted thiosemicarbazone. It was found that the halogen-substitution enhances in most cases the anti-parasitic activity. The meta-fluorinated compound (4g) was identified as the most potent one (IC50= 9.0 μM, CC50 > 200 μM), having a selectivity index (SI = IC50/CC50), which is 4-times higher than that of the non-substituted compound. Slight modification of the reaction conditions employed for the synthesis of some of the benzoylthioureas 3a–3g led to the unexpected formation of novel halogenated 6-amino-1,3,5-thiadiazine-2-thiones.

Oxidorhenium(V) complexes with tetradentate thiourea derivatives

Potentially tetradentate, binegative thiocarbamoylbenzamidines derived from o-phenylenediamines (H2L or H3L) are shown to be suitable ligand systems for oxidorhenium(V) cores. They readily react with (NBu 4)[ReOCl4] or [ReOCl3(PPh3) 2] under formation of monoxido complexes of the composition [ReO{(H)L}(Y)] with various co-ligands (Y = ReO4-, F 3CCO2-, Cl- or methanol) or μ-oxido dimers depending on the reaction conditions applied. Representative products were isolated and studied spectroscopically and by X-ray diffraction. Substitutions in the periphery of the ligands allow the introduction of a carboxylic substituent, which may serve as anchor group for future bioconjugation of appropriate rhenium (or technetium) complexes.

N-BENZIMIDOYLCHLORIDE AUS N-BENZOYLTHIO(SELENO)HARNSTOFFEN UND THIOPHOSGEN

Reactions of thiophosgene with N-benzoylthio(seleno)ureas 1 and 3 yield the N-benzimidoylchlorides 2 and 4.

REAKTIONEN AN NICKEL(II)KOORDINIERTEN N-ACYLTHIOHARNSTOFFEN MIT SAEURECHLORIDEN: EIN EINFACHER ZUGANG FUER NEUE THIOHARNSTOFF-DERIVATE

The reaction of transition metal coordinated N,N-dialkylsubstituted N'-benzoyl thioureas with electrophilic agents differs from the reaction of the non-coordinated ligands.The nickel(II)chelates 1 form with organic acid chlorides RCOCl the N',N'-diacylate