58328-36-2

Basic information

• Product Name: N'-BENZOYL-N,N-DIETHYLTHIOUREA
• Synonyms: N'-BENZOYL-N,N-DIETHYLTHIOUREA;AURORA 2408;1,1-Diethyl-3-benzoylthiourea;1-Benzoyl-3,3-diethylthiourea;N-(Diethylthiocarbamoyl)benzamide;N,N-Diethyl-N'-benzoylthiourea;N-[(Diethylamino)(thiocarbonyl)]benzamide
• CAS NO: 58328-36-2
• Molecular Formula: C₁₂H₁₆N₂OS
• Molecular Weight: 236.33
• Product Categories: Organic Building Blocks;Sulfur Compounds;Thioureas
• Mol File: 58328-36-2.mol
• Article Data: 20

Chemical Properties

• Melting Point: 98-102 °C
• Appearance: /
• CAS DataBase Reference: N'-BENZOYL-N,N-DIETHYLTHIOUREA(CAS DataBase Reference)
• NIST Chemistry Reference: N'-BENZOYL-N,N-DIETHYLTHIOUREA(58328-36-2)
• EPA Substance Registry System: N'-BENZOYL-N,N-DIETHYLTHIOUREA(58328-36-2)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 58328-36-2(Hazardous Substances Data)

Usage

General Description

N'-Benzoyl-N,N-diethylthiourea is a chemical compound used in the synthesis of pharmaceutical drugs and agrochemicals. It is also employed as a catalyst in organic reactions, particularly in the production of rubber. N'-BENZOYL-N,N-DIETHYLTHIOUREA has been studied for its potential antitumor and antiviral activities, and it has shown promise as a chelating agent in metal ion removal processes. N'-Benzoyl-N,N-diethylthiourea is a white, crystalline solid that is insoluble in water but soluble in organic solvents. It is important to handle this compound with care and follow proper safety procedures due to its potential irritant and toxic properties.

Upstream product

• 109-89-7 diethylamine 
• 532-55-8 Benzoyl isothiocyanate 
• 333-20-0 potassium thioacyanate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 79564-21-9 3-Benzoyl-1,1-diethyl-2-(4-hydroxy-1-methyl-pentyl)-isothiourea 
• 79564-19-5 3-Benzoyl-1,1-diethyl-2-(3-hydroxy-butyl)-isothiourea 
• 24760-47-2 N-[di(benzyl)carbamothioyl]benzamide 
• 58676-54-3 bis(1,1-diethyl-3-benzoylthioureato) nickel(II) 
• 1130655-82-1 (Z)-methyl 3-{[benzoyl(diethylamino)carbothioyl]amino}-2-propenoate 
• 1130655-76-3 (Z)-ethyl 3-{[benzoyl(diethylamino)carbothioyl]amino}-2-propenoate 
• 1237084-38-6 dibromo(N-[di(ethyl)carbamothioyl]benzamidate)bis(triphenylarsine)ruthenium(III) 
• 99265-63-1 cis-bis(1,1-diethyl-3-thiobenzoylthioureato) nickel(II) 
• 1342315-72-3 [2-(diethylamino)-4-phenyl-1,3-thiazol-5-yl](phenyl)methanone 
• 75918-14-8 cis-bis-(3,3-diethyl-1-benzoylthioureato)nickel(II) 
• 219823-71-9 cis-bis(1,1-diethyl-3-benzoyl-thioureato)copper(II) 

Relevant articles and documents

Synthesis, characterization and biological applications of bismuth(III) complexes with aroylthiourea ligands

This work describes the synthesis, structural characterization and biological applications of three new bismuth(III) complexes with aroylthiourea-based ligands: [Bi(La)3(HLa)] (1), [Bi2(Lb)4(μ-Lb)2]?2(C3H6O) (2), and [Bi6(μ-Lc)6(μ3-NO3)2(μ6-NO3)](NO3)3?4H2O (3), where HLa = N-benzoyl(N′,N′-diethylthiourea), HLb = N-benzoyl(morpholinylthiourea), and H2Lc = N2,N6-bis(diethylcarbamothioyl)pyridine-2,6-dicarboxamide. The ligands HLa and HLb were considered as monopodal, while H2Lc as bipodal. All compounds were characterized by melting point determination, Fourier-transform infrared spectroscopy (FTIR), proton proton and carbon-13 nuclear magnetic resonance spectroscopy (NMR), mass spectrometry (MS), elemental analysis (EA) and single-crystal X-ray diffraction (SC-XRD). Structural analysis showed that compound 1 was a mononuclear heptacoordinate complex, while compound 2 presented a dinuclear structure and compound 3 was built up by a hexanuclear framework. The proligands, the new complexes, and Bi(NO3)3?5H2O had their antibacterial activities evaluated against E. coli (ATCC 25922), S. aureus (ATCC 25923), and P. aeruginosa (ATCC 27853). The in vitro disk-diffusion (DD) method showed the ability of compound 2 to inhibit two types of bacteria (P. aeruginosa and S. aureus). In the results of minimum inhibitory concentration (MIC), all complexes showed significant activity against the tested microorganisms except for compound 1. The inorganic salt used for comparison showed antibacterial activity only against P. aeruginosa and the ligands showed no apparent activity. Compound 2 presented the best antibacterial activity among the tested substances, and its performance was remarkable even when compared to other similar compounds found in the literature, attesting the importance of targeting bismuth(III) aroylthioureas for further research on new drugs development.

Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents

The new complexes of Pd(II) with N,N-disubstituted-N′-acylthioureas:[(1) [Pd(dppf)(N,N-dimethyl-N′-benzoylthioureato-k2O,S)]PF6, (2) [Pd(dppf)(N,N-diethyl-N′-benzoylthioureato-k2O,S)]PF6, (3) [Pd(dppf)(N,N-dibut

Expanding the donor-acceptor toolbox with a minimal 5-(thiophen-2-yl)-1,3-thiazole core: Transition metal-free synthesis and molecular design for HOMO-LUMO energy modulations

Synthesis of a minimal 5-(thiophen-2-yl)-1,3-thiazole core through a transition metal-free, versatile [4+1] route is reported. DFT calculations on a prototype library of D-A-D-A tetrads established the exquisite HOMO-LUMO energy modulation by varying peri