58328-36-2

Usage

Uses

Used in Pharmaceutical Industry:
N'-Benzoyl-N,N-diethylthiourea is used as an intermediate in the synthesis of pharmaceutical drugs. Its unique chemical structure allows it to be incorporated into various drug molecules, potentially enhancing their therapeutic effects.
Used in Agrochemical Industry:
N'-BENZOYL-N,N-DIETHYLTHIOUREA is also used in the synthesis of agrochemicals, which are chemicals used in agriculture to protect crops from pests and diseases. Its role in the production of these chemicals can contribute to increased crop yields and improved food security.
Used as a Catalyst in Organic Reactions:
N'-Benzoyl-N,N-diethylthiourea is employed as a catalyst in organic reactions, particularly in the production of rubber. Its catalytic properties can improve the efficiency of these reactions, leading to higher yields and better product quality.
Used in Antitumor and Antiviral Research:
N'-BENZOYL-N,N-DIETHYLTHIOUREA has been studied for its potential antitumor and antiviral activities. Its ability to interact with biological targets and modulate cellular processes makes it a promising candidate for the development of new therapeutic agents against cancer and viral infections.
Used as a Chelating Agent in Metal Ion Removal:
N'-Benzoyl-N,N-diethylthiourea has shown promise as a chelating agent in metal ion removal processes. Its ability to form stable complexes with metal ions can be utilized in various applications, such as water treatment and environmental remediation, to remove toxic metal ions from contaminated environments.

Upstream product

• 109-89-7 diethylamine 
• 532-55-8 Benzoyl isothiocyanate 
• 333-20-0 potassium thioacyanate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 79564-21-9 3-Benzoyl-1,1-diethyl-2-(4-hydroxy-1-methyl-pentyl)-isothiourea 
• 79564-19-5 3-Benzoyl-1,1-diethyl-2-(3-hydroxy-butyl)-isothiourea 
• 79564-17-3 3-Benzoyl-1,1-diethyl-2-phenethyl-isothiourea 
• 79564-20-8 3-Benzoyl-1,1-diethyl-2-(3-hydroxy-3-phenyl-propyl)-isothiourea 
• 82655-59-2 N-[(diethylamino)carbonothioyl]benzenecarboximidoyl chloride 
• 70989-46-7 N-benzoyl-N',N'-diphenylthiourea 
• 7245-61-6 N-[(benzoylamino)thioxomethyl]glycine 
• 108875-83-8 6-(N'-benzoyl-thioureido)-hexanoic acid 
• 24760-47-2 N-[di(benzyl)carbamothioyl]benzamide 
• 7204-46-8 1,1-diethylthiourea 
• 58676-54-3 bis(1,1-diethyl-3-benzoylthioureato) nickel(II) 
• 138136-72-8 (N,N-diethyl-N'-benzoyl-thiourea)gold(I) chloride 
• 93180-57-5 bis(N,N-diethyl-N'-benzoylthioureato)mercury(II) 
• 93180-55-3 tris(N,N-diethyl-N'-benzoylthioureato)rhodium(III) 

Relevant academic research and scientific papers

Synthesis, characterization and biological applications of bismuth(III) complexes with aroylthiourea ligands

This work describes the synthesis, structural characterization and biological applications of three new bismuth(III) complexes with aroylthiourea-based ligands: [Bi(La)3(HLa)] (1), [Bi2(Lb)4(μ-Lb)2]?2(C3H6O) (2), and [Bi6(μ-Lc)6(μ3-NO3)2(μ6-NO3)](NO3)3?4H2O (3), where HLa = N-benzoyl(N′,N′-diethylthiourea), HLb = N-benzoyl(morpholinylthiourea), and H2Lc = N2,N6-bis(diethylcarbamothioyl)pyridine-2,6-dicarboxamide. The ligands HLa and HLb were considered as monopodal, while H2Lc as bipodal. All compounds were characterized by melting point determination, Fourier-transform infrared spectroscopy (FTIR), proton proton and carbon-13 nuclear magnetic resonance spectroscopy (NMR), mass spectrometry (MS), elemental analysis (EA) and single-crystal X-ray diffraction (SC-XRD). Structural analysis showed that compound 1 was a mononuclear heptacoordinate complex, while compound 2 presented a dinuclear structure and compound 3 was built up by a hexanuclear framework. The proligands, the new complexes, and Bi(NO3)3?5H2O had their antibacterial activities evaluated against E. coli (ATCC 25922), S. aureus (ATCC 25923), and P. aeruginosa (ATCC 27853). The in vitro disk-diffusion (DD) method showed the ability of compound 2 to inhibit two types of bacteria (P. aeruginosa and S. aureus). In the results of minimum inhibitory concentration (MIC), all complexes showed significant activity against the tested microorganisms except for compound 1. The inorganic salt used for comparison showed antibacterial activity only against P. aeruginosa and the ligands showed no apparent activity. Compound 2 presented the best antibacterial activity among the tested substances, and its performance was remarkable even when compared to other similar compounds found in the literature, attesting the importance of targeting bismuth(III) aroylthioureas for further research on new drugs development.

Thiosemicarbazones and thiadiazines derived from fluorinated benzoylthioureas: Synthesis, crystal structure and anti-Trypanosoma cruzi activity

A series of thiosemicarbazones was obtained by condensation of halogenated N-(diethylaminothiocarbonyl)benzimidoyl chlorides (3b–3h) with 4,4-dimethyl-3-thiosemicarbazide. The activity of the halogenated compounds against the parasite Trypanosoma cruzi was evaluated and compared to the previously reported activity of the corresponding non-substituted thiosemicarbazone. It was found that the halogen-substitution enhances in most cases the anti-parasitic activity. The meta-fluorinated compound (4g) was identified as the most potent one (IC50= 9.0 μM, CC50 > 200 μM), having a selectivity index (SI = IC50/CC50), which is 4-times higher than that of the non-substituted compound. Slight modification of the reaction conditions employed for the synthesis of some of the benzoylthioureas 3a–3g led to the unexpected formation of novel halogenated 6-amino-1,3,5-thiadiazine-2-thiones.

Palladium(II)/N,N-disubstituted-N′-acylthioureas complexes as anti-Mycobacterium tuberculosis and anti-Trypanosoma cruzi agents

The new complexes of Pd(II) with N,N-disubstituted-N′-acylthioureas:[(1) [Pd(dppf)(N,N-dimethyl-N′-benzoylthioureato-k2O,S)]PF6, (2) [Pd(dppf)(N,N-diethyl-N′-benzoylthioureato-k2O,S)]PF6, (3) [Pd(dppf)(N,N-dibut

Expanding the donor-acceptor toolbox with a minimal 5-(thiophen-2-yl)-1,3-thiazole core: Transition metal-free synthesis and molecular design for HOMO-LUMO energy modulations

Synthesis of a minimal 5-(thiophen-2-yl)-1,3-thiazole core through a transition metal-free, versatile [4+1] route is reported. DFT calculations on a prototype library of D-A-D-A tetrads established the exquisite HOMO-LUMO energy modulation by varying peri

Anti-Mycobacterium tuberculosis activity of platinum(II)/N,N-disubstituted-N′-acyl thiourea complexes

Synthesis, characterization and anti-Mycobacterium tuberculosis assays of new platinum(II)/dppf/N,N-disubstituted-N′-acyl thiourea complexes with general formulae [Pt(dppf)(L)]PF6, [dppf = 1,1′-bis(diphenylphosphino)ferrocene; L = N,N-disubstit

On the cytotoxic activity of Pd(II) complexes of N,N-disubstituted- N′-acyl thioureas

The rational design of anticancer drugs is one of the most promising strategies for increasing their cytotoxicity and for minimizing their toxicity. Manipulation of the structure of ligands or of complexes represents a strategy for which is possible to mo

ACCELERATORS FOR CURABLE COMPOSITIONS

Benzoylthiourea or benzoylthiourethane derivatives as cure accelerators for curable compositions are provided.

ACCELERATORS FOR TWO PART CURABLE COMPOSITIONS

Benzoylthiourea or benzoylthiourethane derivatives as cure accelerators for two part curable compositions are provided.

Bis- and tris-chelates of NiII, CuII, CoII and FeIII bound to N,N-dialkyl/alkyl aryl-N′-benzoylthiourea ligands

Bis- and tris-chelates (1-5) of Ni(II), Cu(II), Fe(III) and Co(II) with two O,S donor substituted benzoylthiourea based ligands 3,3-diethyl-1- benzoylthiourea (HL1) and 3-methyl-3-phenyl-1-benzoylthiourea (HL2) have been synthesized

Tris-chelate complexes of cobalt(III) with N-[di(alkyl/aryl)carbamothioyl] benzamide derivatives: Synthesis, crystallography and catalytic activity in TBHP oxidation of alcohols

New six coordinated tris-chelate cobalt(III) complexes of the type [Co(L)3] (1-4) {where HL = N-[di(alkyl/aryl)carbamothioyl]benzamide derivatives}were prepared from the reaction between CoCl2· 6H2O and N-[di(alkyl/aryl)carbamothioyl]benzamide in ethanol and characterized by elemental analysis and spectral data (UV/Vis, IR, 1H & 13C NMR). The molecular structure of a representative complex [Co(L1)3] (1) [where HL1 = N-(diisopropylcarbamothioyl)benzamide], was determined by single crystal X-ray diffraction method and reveals a distorted octahedral geometry and a facial configuration of S atoms around the Co(III) center. These complexes act as efficient catalysts for the oxidation of alcohols to their corresponding aldehydes or ketones in presence of tert-butyl hydroperoxide (TBHP) at 80°C.