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Usage

Uses

Used in Pharmaceutical Industry:
3-(Methylsulphonyl)benzyl bromide 97% is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its alkylating properties allow for the modification of drug molecules, enhancing their therapeutic potential and effectiveness in treating different medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, 3-(Methylsulphonyl)benzyl bromide 97% is utilized as a key component in the synthesis of bioactive molecules for crop protection and pest management. Its ability to introduce the methylsulphonylbenzyl group contributes to the creation of novel agrochemicals with improved efficacy and selectivity.
Used in Specialty Chemicals Production:
3-(Methylsulphonyl)benzyl bromide 97% is employed as a reagent in the manufacturing process of specialty chemicals. Its unique functional group introduction capability is crucial for achieving specific chemical properties required in various industrial applications.
Used in Organic Synthesis Research:
As a reagent in organic synthesis research, 3-(Methylsulphonyl)benzyl bromide 97% is instrumental in the exploration and development of complex organic molecules. Its high purity makes it an ideal candidate for precise experimental conditions, contributing to the advancement of chemical knowledge and innovation.

Upstream product

• 591-17-3 meta-bromotoluene 
• 220798-39-0 (3-(methylsulfonyl)phenyl)methanol 
• 1877-64-1 2-(3-(methylsulfonyl)phenyl)acetic acid 
• 10355-06-3 methyl 3-methylphenyl sulfone 

Downstream Products

• 866206-72-6 N-(1-(3-(methylsulfonyl)benzyl)piperidin-4-yl)-6-chlorothieno[2,3-d]pyrimidin-4-amine 
• 1020736-59-7 3-methyl-4-{3-[3-(methylsulfonyl)benzyl]phenyl}-8-(trifluoromethyl)quinoline 
• 1167571-21-2 2-isopropyl-3-(3-{[3-(methylsulfonyl)benzyl]oxy}phenyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine 
• 1168154-99-1 2-ethyl-1-(4-{[3-(methylsulfonyl)benzyl]oxy}phenyl)-4-(trifluoromethyl)-1H-benzimidazole 
• 1228439-40-4 C₂₂H₂₅NO₅S 
• 1228439-92-6 C₂₅H₃₁NO₆S 
• 1112985-32-6 4-(3-{[3-(methylsulfonyl)benzyl]oxy}phenyl)-8-(trifluoromethyl)quinazoline 
• 1206713-03-2 [6-bromo-7-(3-methanesulphonylbenzyloxy)quinazolin-4-yl](isopropyl)amine 
• 1206713-19-0 (E/Z)-N'-[2-cyano-5-(3-methanesulphonylbenzyloxy)-4-bromophenyl]-N,N-dimethylformamidine 

Relevant academic research and scientific papers

Lifitegrast intermediate and preparation method thereof

The invention relates to the field of pharmaceutical and chemical production, and discloses a lifitegrast intermediate and a preparation method thereof. A reaction route of the preparation method is as described in the specification. The preparation metho

Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues

A series of analogues of the (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) receptor agonist BnTetAMPA (5b) were synthesized and characterized pharmacologically in radioligand binding assays at native and cloned AMPA receptors and functionally by two-electrode voltage clamp electrophysiology at the four homomeric AMPA receptors expressed in Xenopus laevis oocytes. The analogues 6 and 7 exhibit very different pharmacological profiles with binding affinity preference for the subtypes GluA1 and GluA3, respectively. X-ray crystal structures of three ligands (6, 7, and 8) in complex with the agonist binding domain (ABD) of GluA2 show that they induce full domain closure despite their low agonist efficacies. Trp767 in GluA2 ABD could be an important determinant for partial agonism of this compound series at AMPA receptors, since agonist efficacy also correlated with the location of the Trp767 side chain.

Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments

The present invention relates to sulphone-substituted quinazoline derivatives of the formula (I), processes for their preparation and their use as a medicament for the treatment of various diseases.