95123-62-9

Upstream product

• 401-95-6 3,5-Bis(trifluoromethyl)benzaldehyde 
• 2136-75-6 (triphenylphosphoranylidene)acetaldehyde 
• 109-99-9 tetrahydrofuran 
• 826994-13-2 (E)-3-(3,5-bis(trifluoromethyl)phenyl)prop-2-en-1-ol 

Downstream Products

• 848863-57-0 (E,E)-1,4-di-(3,5-bis(trifluoromethyl)phenyl)-1,3-butadiene 
• 95123-66-3 3,5-bis(trifluoromethyl)-trans-cinnamaldehyde dimethyl ketal 

Relevant academic research and scientific papers

Regioselective α-Deuteration of Michael Acceptors Mediated by Isopropylamine in D2O/AcOD

Site-specific hydrogen/deuterium exchange is an important method to access deuterated compounds for chemical and biological studies. Herein is reported the first method for the regioselective α-deuteration of enals and enones. The transformation features D2O and AcOD as deuterium sources and amines as organocatalysts. The deuteration strategy is scalable and works on enals with a variety of substituted arene or heterocycle motifs as well as enones. The method has been applied to the synthesis of deuterated drug precursors.

Trifluoromethyl groups in crystal design of 1,4-diphenyl-1,3-butadienes for topochemical [2 + 2] photodimerization

(Figure Presented) UV irradiation of the powdered crystalline sample of each of three (E,E)-1,4-di(trifluoromethyl-substituted)phenyl-1,3-butadienes (1-3) was found to yield a single [2 + 2] cycloaddition product in the solid state. Moreover, upon irradia

7-aryl-6(Z)-heptatrienoic acid retinamides

Novel trienoic retinoid compounds of with apoptotic activity useful for the prevention and treatment of cancer.