827-63-4

Upstream product

• 64-17-5 ethanol 
• 620-22-4 3-Methylbenzonitrile 

Downstream Products

• 92666-77-8 9,10-Diethoxy-4-m-tolyl-1,6,7,11b-tetrahydro-pyrimido[6,1-a]isoquinolin-2-one 
• 92666-87-0 2-[6,7-Dimethoxy-2-(3-methyl-benzoyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-acetamide 
• 217966-22-8 5-(3-methylphenyl)-3-<4-(4-nitrophenyl)piperazin-1-yl-methyl>-1H-1,2,4-triazole 
• 206051-44-7 3-Adamantan-1-yl-5-m-tolyl-1H-[1,2,4]triazole 
• 33243-85-5 N-Phenyl-ethyl-m-methylbenzhydrazonat 
• 1569897-02-4 2-(m-tolyl)[1,2,4]triazolo[1,5-a]pyridine 
• 64113-85-5 2-cyano-4-methylbiphenyl 

Relevant academic research and scientific papers

Rhodium-Catalyzed Relay Carbenoid Functionalization of Aromatic C-H Bonds toward Fused Heteroarenes

A rhodium-catalyzed annulation between ethyl benzimidates and α- aroyl sulfur ylides was developed, affording a series of pyrano[4,3,2-ij]isoquinoline derivatives in moderate to good yields with good functional group compatibility. The procedure featured

Synthesis of Isoquinolines through IrIII-Catalyzed C–H Activation/Annulation from Benzimidates with Hydroxylisopropylalkynes

An IrIII-catalyzed cascade reaction consisting of C–H activation/annulation of benzimidates with hydroxylisopropylalkynes is reported. A broad range of isoquinolines has been prepared in one step with good functiona-group tolerance and high eff

Controllable Rh(III)-Catalyzed C-H Arylation and Dealcoholization: Access to Biphenyl-2-carbonitriles and Biphenyl-2-carbimidates

A controllable Rh(III)-catalyzed C-H arylation and dealcoholization of benzimidates with arylboronic esters was developed, delivering various biphenyl-2-carbonitriles and biphenyl-2-carbimidates by simply tuning the reaction conditions. This approach features high efficiency, good functional group tolerance, and easy operation. It also provides an alternative pathway to thoroughly exploit the directing group in transition-metal-catalyzed C-H activations.

Synthesis of Functionalized Indenones via Rh-Catalyzed C-H Activation Cascade Reaction

An efficient and expeditious protocol for the synthesis of diverse difunctionalized indenones through rhodium-catalyzed C-H activation and multistep cascade reaction of benzimidates and alkenes has been developed. The transformation involves the cleavage and formation of multiple bonds in one pot under mild reaction conditions, and Mn(OAc)2 plays an important role in the reaction.

Cobalt-Catalyzed Oxidant-Free Spirocycle Synthesis by Liberation of Hydrogen

The first example of oxidant-free cobalt-catalyzed synthesis of five-membered spirocycles is reported from benzimidates and maleimides utilizing nitrobenzene as promoter. In contrast to previously known cobalt-catalyzed oxidative C-H functionalization rea

Synthesis of 1H-Indazoles from Imidates and Nitrosobenzenes via Synergistic Rhodium/Copper Catalysis

Nitrosobenzenes have been used as a convenient aminating reagent for the efficient synthesis of 1H-indazoles via rhodium and copper catalyzed C-H activation and C-N/N-N coupling. The reaction occurred under redox-neutral conditions with high efficiency and functional group tolerance. Moreover, a rhodacyclic imidate complex has been identified as a key intermediate.

Rh(III)-Catalyzed C-C/C-N Coupling of Imidates with α-Diazo Imidamide: Synthesis of Isoquinoline-Fused Indoles

Imidate esters and diazo compounds have been established as bifunctional substrates for the construction of biologically active fused heterocycles via rhodium-catalyzed C-H activation and C-C/C-N coupling. This reaction occurs under mild conditions with high efficiency, step economy, and low catalyst loading.