64113-85-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Methyl-[1,1'-biphenyl]-2-carbonitrile is used as a key intermediate in the synthesis of pharmaceuticals for its ability to be easily modified and incorporated into complex molecular structures. Its presence in the molecular framework can contribute to the development of new drugs with improved therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Methyl-[1,1'-biphenyl]-2-carbonitrile is used as a versatile building block for the preparation of a wide range of organic compounds. Its reactivity allows for various chemical reactions, facilitating the creation of diverse chemical entities.
Used in Materials Science:
4-Methyl-[1,1'-biphenyl]-2-carbonitrile may also have potential applications in materials science, where it could be utilized in the development of new materials with specific properties. Its structural features can be leveraged to enhance material characteristics such as stability, conductivity, or other desired attributes.
Safety Note:
It is important to handle 4-Methyl-[1,1'-biphenyl]-2-carbonitrile with caution, as nitriles can be hazardous if not properly managed. Adequate safety measures should be taken during its use, storage, and disposal to minimize risks associated with this chemical compound.

Upstream product

• 39554-87-5 4-methyl-2-nitrobiphenyl 
• 151-50-8 potassium cyanide 
• 54147-94-3 2-amino-4-methylbiphenyl 
• 2042-37-7 o-cyanobromobenzene 
• 5720-05-8 4-methylphenylboronic acid 
• 873-32-5 2-Chlorobenzonitrile 
• 14221-01-3 tetrakis(triphenylphosphine) palladium⁽⁰⁾ 
• 497-19-8 sodium carbonate 
• 106-38-7 para-bromotoluene 
• 31614-66-1 tributyl(p-tolyl)stannane 
• 591-50-4 iodobenzene 
• 620-22-4 3-Methylbenzonitrile 
• 98-80-6 phenylboronic acid 
• 827-63-4 ethyl 3-methylbenzimidate 

Downstream Products

• 114772-54-2 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile 
• 1613289-91-0 6-cyclohexyl-3-methylphenanthridine 

Relevant academic research and scientific papers

Synthesis of biphenyl-2-carbonitrile derivatives via a palladium-catalyzed sp2 C-H bond activation using cyano as a directing group

PdII-catalyzed aromatic C-H bond activation using cyano as a directing group was carried out in TFA medium. Biphenyl-2-carbonitrile derivatives were therefore synthesized from aryl nitriles and aryl halides in moderate to good yields.

Controllable Rh(III)-Catalyzed C-H Arylation and Dealcoholization: Access to Biphenyl-2-carbonitriles and Biphenyl-2-carbimidates

A controllable Rh(III)-catalyzed C-H arylation and dealcoholization of benzimidates with arylboronic esters was developed, delivering various biphenyl-2-carbonitriles and biphenyl-2-carbimidates by simply tuning the reaction conditions. This approach features high efficiency, good functional group tolerance, and easy operation. It also provides an alternative pathway to thoroughly exploit the directing group in transition-metal-catalyzed C-H activations.

PPARG MODULATORS FOR TREATMENT OF OSTEOPOROSIS

The invention provides methods of treatment of a progressive bone disease, such as osteoporosis, Paget's Disease, multiple myeloma, or hyperparathyroidism, comprising administration of an effective amount of a non-agonist PPARG modulator to a patient afflicted with the disease.

MODULATORS OF THE METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 5 AND USES THEREOF

Disclosed are compounds and pharmaceutically acceptable salts, which are modulators of the metabotropic glutamate receptor 5, for use in treating drug abuse and other mental disorders, for example, a compound of Formula (I), wherein X, Y, and R1/sup

Process for preparing biphenyls using palladacycles as catalysts

The invention relates to a process for preparing biphenyls of the formula (I) STR1 where R1a to R10a are, independently of one another, hydrogen, C1 -C12 -alkyl, C1 -C12 -alkenyl, C1 -C12 -alkynyl, alkoxy-(C1 -C12), acyloxy-(C1 -C12), O-phenyl, aryl, heteroaryl, fluorine, chlorine, OH, NO2, CN, COOH, CHO, SO3 H, SO2 R, SOR, NH2, NH-alkyl-(C1 -C12), N-alkyl2 -(C1 -C12), C-Hal3, NHCO-alkyl-(C1 -C8), CONH-alkyl-(C1 -C4), CON-(alkyl)2 -(C1 -C4), COO-alkyl-(C1 -C12), CONH2, CO-alkyl-(C1 -C12), NHCOH, NHCOO-alkyl-(C1 -C8), CO-phenyl, COO-phenyl, CHCHCO2 -alkyl-(C1 -C12), CHCHCO2 H, PO-phenyl2, PO-alkyl2 -(C1 -C8), by reaction of haloaromatics or aryl sulfonates of the formula (II) STR2 with arylboron derivatives of the formula III STR3 where R1a to R10a are as defined above and X is bromine, chlorine or OSO2 CF3, OSO2 -aryl, OSO2 -alkyl and Y is B(OH)2, B(O-alkyl)2, B(O-aryl)2, wherein a palladium compound of the formula (IV) STR4 where R1, R2, R3, R4, R5, R6 are, independently of one another, hydrogen, (C1 -C4)-alkyl, (C5 -C8)-cycloalkyl, (C1 -C4)-alkoxy, fluorine, NH2, NH-alkyl(C1 -C4), N(alkyl)2 -(C1 -C4), CO2 -alkyl-(C1 -C4), OCO-alkyl-(C1 -C4) or phenyl, or R1 and R2, R2 and R3, R3 and R4, R5 and R6 together form an aliphatic or aromatic ring, and R7, R8 are (C1 -C8)-alkyl, (C3 -C12)-cycloalkyl, substituted or unsubstituted aryl and Y is an anion of an inorganic or organic acid, is used as catalyst.

Substituted pyrazino 2,3-D pyrimidinones as angiotensin II antagonists

Novel substituted pyrazino[2,3-d]pyrimidinones of formula (I), are angiotensin II antagonists, useful in the treatment of hypertension and related disorders and in certain CNS disorders.

Benzo-fused lactams that promote the release of growth hormone

There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such benzo-fused lactams as the active ingredient thereof are also disclosed.

Process for the manufacture of nitriles

The invention provides a novel process for the manufacture of biphenylcarbonitriles of the formula III as defined hereinafter which are useful for the production of certain known imidazole derivatives and certain novel quinoline derivatives which have angiotensin II inhibitory activity. The process involves a palladium- or nickel-catalysed reaction of a boron compound of the formula II with a nitrile of the formula III in which the variables L1, L2, Q1 and Q2 have the various meanings defined hereinafter. Certain of the biphenylcarbonitriles are novel and are provided as a further feature of the invention. The invention also provides a novel process for the production of the known and novel angiotensin II inhibitors of formula VI and VII as defined hereinafter.

Process for the preparation of nitriles

The invention provides a novel process for the manufacture of biphenylcarbonitriles of the formula I as defined hereinafter which are useful for the production of certain known imidazole derivatives and certain novel quinoline derivatives which have angio

Antihypertensive products, a process for their preparation and pharmaceutical compositions containing them.

Fermentation of the microorganism Actinoplanacete sp. in the presence of the Angiotensin II (A II) receptor antagonist yields a 5-hydroxymethyl and a 7-hydroxymethyl analog, both of which are also A II antagonists useful in the treatment of hypertension and congestive heart failure and other indications known to respond to A II antagonists.