64113-85-5Relevant articles and documents
Synthesis of biphenyl-2-carbonitrile derivatives via a palladium-catalyzed sp2 C-H bond activation using cyano as a directing group
Li, Wu,Xu, Zhipeng,Sun, Peipei,Jiang, Xiaoqing,Fang, Min
, p. 1286 - 1289 (2011)
PdII-catalyzed aromatic C-H bond activation using cyano as a directing group was carried out in TFA medium. Biphenyl-2-carbonitrile derivatives were therefore synthesized from aryl nitriles and aryl halides in moderate to good yields.
PPARG MODULATORS FOR TREATMENT OF OSTEOPOROSIS
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Page/Page column 240; 266, (2015/11/09)
The invention provides methods of treatment of a progressive bone disease, such as osteoporosis, Paget's Disease, multiple myeloma, or hyperparathyroidism, comprising administration of an effective amount of a non-agonist PPARG modulator to a patient afflicted with the disease.
Process for preparing biphenyls using palladacycles as catalysts
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, (2008/06/13)
The invention relates to a process for preparing biphenyls of the formula (I) STR1 where R1a to R10a are, independently of one another, hydrogen, C1 -C12 -alkyl, C1 -C12 -alkenyl, C1 -C12 -alkynyl, alkoxy-(C1 -C12), acyloxy-(C1 -C12), O-phenyl, aryl, heteroaryl, fluorine, chlorine, OH, NO2, CN, COOH, CHO, SO3 H, SO2 R, SOR, NH2, NH-alkyl-(C1 -C12), N-alkyl2 -(C1 -C12), C-Hal3, NHCO-alkyl-(C1 -C8), CONH-alkyl-(C1 -C4), CON-(alkyl)2 -(C1 -C4), COO-alkyl-(C1 -C12), CONH2, CO-alkyl-(C1 -C12), NHCOH, NHCOO-alkyl-(C1 -C8), CO-phenyl, COO-phenyl, CHCHCO2 -alkyl-(C1 -C12), CHCHCO2 H, PO-phenyl2, PO-alkyl2 -(C1 -C8), by reaction of haloaromatics or aryl sulfonates of the formula (II) STR2 with arylboron derivatives of the formula III STR3 where R1a to R10a are as defined above and X is bromine, chlorine or OSO2 CF3, OSO2 -aryl, OSO2 -alkyl and Y is B(OH)2, B(O-alkyl)2, B(O-aryl)2, wherein a palladium compound of the formula (IV) STR4 where R1, R2, R3, R4, R5, R6 are, independently of one another, hydrogen, (C1 -C4)-alkyl, (C5 -C8)-cycloalkyl, (C1 -C4)-alkoxy, fluorine, NH2, NH-alkyl(C1 -C4), N(alkyl)2 -(C1 -C4), CO2 -alkyl-(C1 -C4), OCO-alkyl-(C1 -C4) or phenyl, or R1 and R2, R2 and R3, R3 and R4, R5 and R6 together form an aliphatic or aromatic ring, and R7, R8 are (C1 -C8)-alkyl, (C3 -C12)-cycloalkyl, substituted or unsubstituted aryl and Y is an anion of an inorganic or organic acid, is used as catalyst.