82703-19-3

Upstream product

• 3360-41-6 4-phenyl-butan-1-ol 
• 65512-08-5 4-phenylbutyl methanesulfonate 
• 138504-80-0 2-(4-phenylbutoxy)isoindoline-1,3-dione 

Downstream Products

• 4052-74-8 6β-(2-phenoxy-acetylamino)-penicillanic acid 4-phenyl-butoxyamide 
• 867168-90-9 2-amino-3-hydroxy-propionaldehyde O-(4-phenyl-butyl)-oxime 
• 889666-53-9 C₄₅H₆₉N₃O₁₂ 

Relevant academic research and scientific papers

δ-C-H Mono- And Dihalogenation of Alcohols

Alkoxy radicals have long been known to enable remote C-H functionalization via 1,5-hydrogen atom abstraction. However, methods for their generation traditionally have relied upon highly oxidizing metals, ultraviolet radiation, or preformed peroxide intermediates, which has prevented the development of many desirable transformations. Herein we report a new bench-stable precursor that decomposes to free alkoxy radicals via a previously unreported single-electron oxidation pathway. This new precursor enables the fluorination and chlorination of remote C-H bonds under exceptionally mild conditions with exceedingly high monoselectivity. Iterative use of this precursor enables the introduction of a second halogen atom, granting access to remote dihalide motifs, including CF2 and CFCl.

A solid-phase approach to DDB derivatives

Since the discovery of 2,2′-dimethoxycarbonyl-4,4-dimethoxy-5,6, 5′,6′-biomethylenedioxy-biphenyl (DDB) as a potent anti-HBV agent, we have studied the structure-activity relationships of 4,4′-dimethoxy-5, 6,5′,6′-dimethenedioxy-2-alkyloxycarbonyl-2′-(4-substituted benzyl piperazin-1-yl)carbonyl-biphenyl as anti-HBV agents. Therefore, it is rational to extend this study to the 3,3′-disustituted-4,4′- dimethoxy-5,6,5′,6′-dimethenedioxy-2-alkyloxycarbonyl-2′- Serine derivatives. Thus, in an attempt to develop an efficient method for the preparation of a large number of DDB derivatives, the reaction between a DDB acid chloride and serine derivatives on solid support was studied. The structure of resulted compounds was confirmed by LC-MS and 1H NMR analysis. Compounds 2a, 2d, 2f, 2j showed in vitro anti-HBV activity without significant toxicity up to 100 μM.

Cyclohexenone oxime ethers, their preparation and their use as herbicides

Cyclohexenone oxime ethers of the formula I STR1 where R1 is alkyl, X is halogen, n is from 1 to 5, R2 is alkoxyalkyl or alkylthioalkyl, unsubstituted of substituted cycloalkyl or cycloalkenyl, an unsubstituted or substituted 5-membe