827031-10-7

Basic information

• Product Name: 4-Quinazolinamine, N-[4-(difluoromethoxy)phenyl]-2-methyl-
• CAS NO: 827031-10-7
• Molecular Formula: C16H13F2N3O
• Molecular Weight: 301.296
• Mol File: 827031-10-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-Quinazolinamine, N-[4-(difluoromethoxy)phenyl]-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Quinazolinamine, N-[4-(difluoromethoxy)phenyl]-2-methyl-(827031-10-7)
• EPA Substance Registry System: 4-Quinazolinamine, N-[4-(difluoromethoxy)phenyl]-2-methyl-(827031-10-7)

Safety Data

• Hazardous Substances Data: 827031-10-7(Hazardous Substances Data)

Upstream product

• 22236-10-8 4-difluoromethoxyaniline 
• 6484-24-8 2-methyl-4-chloroquinazoline 

Relevant articles and documents

Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration

As a continuation of our structure-activity relationship (SAR) studies on 4-anilinoquinazolines as potent apoptosis inducers and to identify anticancer development candidates, we explored the replacement of the 2-Cl group in our lead compound 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (6b, EP128265, MPI-0441138) by other functional groups. This SAR study and lead optimization resulted in the identification of N-(4-methoxyphenyl)-N,2- dimethylquinazolin-4-amine (6h, EP128495, MPC-6827) as an anticancer clinical candidate. Compound 6h was found to be a potent apoptosis inducer with EC 50 of 2 nM in our cell-based apoptosis induction assay. It also has excellent blood brain barrier penetration, and is highly efficacious in human MX-1 breast and other mouse xenograft cancer models.