827038-91-5Relevant articles and documents
Aminothiazole inhibitors of HCV RNA polymerase
Shipps Jr., Gerald W.,Deng, Yongqi,Wang, Tong,Popovici-Muller, Janeta,Curran, Patrick J.,Rosner, Kristin E.,Cooper, Alan B.,Girijavallabhan, Viyyoor,Butkiewicz, Nancy,Cable, Michael
, p. 115 - 119 (2007/10/03)
Aminothiazole-based inhibitors designed for HCV polymerase display low micromolar potencies in biochemical assays. These compounds show a stringent preference for a cyclohexyl hydrophobe at the 2-amino position. The composition of these compounds suggests that they may be interacting at a recently discovered allosteric site on the polymerase.