82717-97-3

Basic information

• Product Name: 1H-Indole-2-carboxylic acid, octahydro-, phenylmethyl ester, hydrochloride
• CAS NO: 82717-97-3
• Molecular Formula: C16H21NO2.ClH
• Molecular Weight: 295.809
• Mol File: 82717-97-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Indole-2-carboxylic acid, octahydro-, phenylmethyl ester, hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-2-carboxylic acid, octahydro-, phenylmethyl ester, hydrochloride(82717-97-3)
• EPA Substance Registry System: 1H-Indole-2-carboxylic acid, octahydro-, phenylmethyl ester, hydrochloride(82717-97-3)

Safety Data

• Hazardous Substances Data: 82717-97-3(Hazardous Substances Data)

Upstream product

• 1004292-98-1 (+/-)-trans-octahydroindole-2-carboxylic acid hydrochloride 
• 100-51-6 benzyl alcohol 
• 1004292-98-1 Cis,exo-perhydroindole-2-L-carboxylic acid hydrochloride 

Downstream Products

• 86647-57-6 (2S,3aS,7aS)-phenylmethyl octahydroindole-2-carboxylate hydrochloride 
• 87679-37-6 trandolapril 
• 82717-90-6 cis,syn-octahydro-1H-indole-2(S)-carboxylic acid, phenylmethylester 
• 145641-35-6 phenylmethyl-(2S,3aR,7aS)-octahydroindole-2-carboxylate hydrochloride 

Relevant articles and documents

Process for the synthesis of ?2S, 3aR, 7aS|-octahydroindole-2-carboxylic acid and its conversion to trandolapril

The present invention describes a novel method for the synthesis of (2S,3aR,7aS)-octahydroindole-2-carboxylic acid of formula III using a new intermediate of formula II and conversion of the product of formula-III to trandolapril of formula I

PREPARATION OF TRANDOLAPRIL

A process for preparing trandolapril, (2S,3aR,7aS)-1-[(S)-N-[(S)-1-Carboxy-3-phenylpropyl]alanyl]hexahydro-2-indolinecarboxylic acid, 1-ethyl ester, and intermediates that are useful in the process.