827328-29-0

Basic information

• Product Name: N¹-(3-methoxybenzyl)-N²,N²-dimethylethane-1,2-diamine
• Synonyms: N¹-(3-methoxybenzyl)-N²,N²-dimethylethane-1,2-diamine
• CAS NO: 827328-29-0
• Molecular Weight: 208.304
• Mol File: 827328-29-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N¹-(3-methoxybenzyl)-N²,N²-dimethylethane-1,2-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N¹-(3-methoxybenzyl)-N²,N²-dimethylethane-1,2-diamine(827328-29-0)
• EPA Substance Registry System: N¹-(3-methoxybenzyl)-N²,N²-dimethylethane-1,2-diamine(827328-29-0)

Safety Data

• Hazardous Substances Data: 827328-29-0(Hazardous Substances Data)

Upstream product

• 108-00-9 N,N-dimethylethylenediamine 
• 591-31-1 3-methoxy-benzaldehyde 

Downstream Products

• 1219729-05-1 C₁₉H₂₄BrN₃O₂ 
• 1219722-72-1 3-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-1-(2-(dimethylamino)ethyl)-1-(3-methoxybenzyl)urea 
• 1219729-17-5 C₂₃H₃₃BrN₄O₃ 
• 1219722-60-7 3-(4-(1H-pyrazol-4-yl)phenyl)-1-(2-(dimethylamino)ethyl)-1-(3-methoxybenzyl)urea 
• 1202252-27-4 C₂₀H₂₂BrN₃O₂S 
• 1296199-77-3 N-(2-(dimethylamino)ethyl)-N-(3-methoxybenzyl)-6-(1H-pyrazol-4-yl)-1-(2-(pyrrolidin-1-yl)ethyl)-1H-indole-3-carboxamide 
• 1296199-69-3 N-(2-(dimethylamino)ethyl)-N-(3-methoxybenzyl)-1-methyl-6-(1H-pyrazol-4-yl)-1H-indole-3-carboxamide 

Relevant articles and documents

Biphenyl formamide urea compound, and preparation method and application thereof

The invention belongs to the technical field of medicines, particularly relates to the field of treatment of tumor-related diseases, and relates to a biphenyl formamide urea compound, and a preparation method and application thereof. In order to solve the problem that the effect of a ROCK inhibitor in the prior art still needs to be improved, the invention provides the biphenyl formamide urea compound represented by formula (I) shown in the specification. The novel biphenyl formamide urea ROCKI inhibitor is prepared through a dominant fragment heterozygosis design strategy, so that the novel biphenyl formamide urea ROCKI inhibitor can simultaneously extend into target key binding regions (a pocket A and a pocket D) to improve the target affinity with the ROCKI inhibitor; further, the ROCK inhibition effect and the anti-tumor effect are improved.