827344-06-9Relevant academic research and scientific papers
Discovery of CS-0777: A potent, selective, and orally active S1P 1 agonist
Nishi, Takahide,Miyazaki, Shojiro,Takemoto, Toshiyasu,Suzuki, Keisuke,Iio, Yukiko,Nakajima, Katsuyoshi,Ohnuki, Takashi,Kawase, Yumi,Nara, Futoshi,Inaba, Shinichi,Izumi, Takashi,Yuita, Hiroshi,Oshima, Keiko,Doi, Hiromi,Inoue, Ryotaku,Tomisato, Wataru,Kagari, Takashi,Shimozato, Takaichi
, p. 368 - 372 (2011/07/08)
CS-0777 (3) is phosphorylated in vivo, and the phosphate of CS-0777 (CS-0777-P) (4) acts as a selective S1P receptor-1 (S1P1) modulator. We report herein the synthesis of CS-0777 and CS-0777-P, pharmacological effects such as S1P1 an
AMINO ALCOHOL COMPOUND
-
Page/Page column 38, (2010/11/25)
A pharmaceutical composition is provided that has a low toxicity, demonstrates superior physicochemical properties and pharmacokinetics, and has superior peripheral blood lymphocyte count lowering activity. The pharmaceutical composition contains a compound having general formula (I): (wherein R 1 represents a methyl group or an ethyl group, R 2 represents a methyl group or an ethyl group, and R 3 represents a phenyl group substituted with 1 to 3 substituents selected from the group consisting of a halogen atom, a lower alkyl group, a cycloalkyl group, a lower alkoxy group, a halogeno lower alkyl group, a lower aliphatic acyl group and a cyano group), a pharmacologically acceptable salt thereof or a pharmacologically acceptable ester thereof.
