827348-53-8Relevant academic research and scientific papers
Modular synthesis of pantetheine and phosphopantetheine
Mandel, Alexander L.,La Clair, James J.,Burkart, Michael D.
, p. 4801 - 4803 (2004)
(Chemical Equation Presented) D-Pantetheine and D-phosphopantetheine, precursors to coenzyme A, have been synthesized though a linear sequence from three modules (M1-M3) in 9 and 10 steps, respectively. These routes provide access to analogues of coenzyme A containing modified cystamines, β-alanines, and pantoic acid residues. All three modules were joined using conventional methods of peptide synthesis. The chiral component, M3, was derived from D-pantolactone.
