82756-06-7

Basic information

• Product Name: Acetic acid, 2-oxo-2-[(2-phenylethyl)aMino]-, ethyl ester
• Synonyms: Acetic acid, 2-oxo-2-[(2-phenylethyl)aMino]-, ethyl ester;Ethyl 2-oxo-2-(phenethylamino)acetate
• CAS NO: 82756-06-7
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.2524
• Mol File: 82756-06-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Acetic acid, 2-oxo-2-[(2-phenylethyl)aMino]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, 2-oxo-2-[(2-phenylethyl)aMino]-, ethyl ester(82756-06-7)
• EPA Substance Registry System: Acetic acid, 2-oxo-2-[(2-phenylethyl)aMino]-, ethyl ester(82756-06-7)

Safety Data

• Hazardous Substances Data: 82756-06-7(Hazardous Substances Data)

Usage

Uses

Used in Flavoring and Fragrance Industry:
Acetic acid, 2-oxo-2-[(2-phenylethyl)amino]-, ethyl ester is used as a flavoring and fragrance ingredient in the food and cosmetic industries. Its fruity, floral scent adds a pleasant aroma to various products, enhancing their overall appeal to consumers.
Used in Pharmaceutical Production:
This chemical compound is also used in the production of pharmaceuticals. Its unique properties make it a valuable component in the development of various medications, contributing to their effectiveness and safety.
Used as a Solvent in Organic Synthesis:
Acetic acid, 2-oxo-2-[(2-phenylethyl)amino]-, ethyl ester serves as a solvent in organic synthesis. Its ability to dissolve a wide range of substances makes it a versatile and useful component in various chemical reactions and processes.
Overall, Acetic acid, 2-oxo-2-[(2-phenylethyl)amino]-, ethyl ester is a versatile chemical compound with a variety of applications in different industries, including flavoring and fragrance, pharmaceutical production, and organic synthesis. Its unique properties, such as its fruity, floral scent and its ability to dissolve various substances, make it a valuable asset in these fields.

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 64-04-0 phenethylamine 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 88612-00-4 3,4-dihydro-isoquinoline-1-carboxylic acid ethyl ester 
• 1943-82-4 phenethyl isocyanate 
• 22051-02-1 1,1-diphenyl-1,3,4,5-tetrahydro-benz[d]azepin-2-one 

Relevant articles and documents

Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates

We report a new electrochemical supporting-electrolyte-free method for synthesizing ureas, carbamates, and thiocarbamates via the oxidation of oxamic acids. This simple, practical, and phosgene-free route includes the generation of an isocyanate intermediate in situ via anodic decarboxylation of an oxamic acid in the presence of an organic base, followed by the one-pot addition of suitable nucleophiles to afford the corresponding ureas, carbamates, and thiocarbamates. This procedure is applicable to different amines, alcohols, and thiols. Furthermore, when single-pass continuous electrochemical flow conditions were used and this reaction was run in a carbon graphite Cgr/Cgr flow cell, urea compounds could be obtained in high yields within a residence time of 6 min, unlocking access to substrates that were inaccessible under batch conditions while being easily scalable.

Visible-light mediated carbamoyl radical addition to heteroarenes

The generation of carbamoyl radicals, followed by their addition to heteroarenes, was performed under mild conditions through a metal-free photocatalyzed decarboxylation of oxamic acids. The process has been applied to the carbamoylation of heteroaromatic bases using α-aminoacid-derived oxamic acids, leading to the corresponding amides without racemization.

METHOD FOR PRODUCING BENZAZEPINONE

It is an object of the present invention to provide 2-iminocarboxylic acid derivatives, and a practically suitable industrial method for producing benzazepinones in a short process under mild conditions. The present invention provides a method for producing a benzazepinone or a salt thereof, which comprises opening a ring of an isoquinoline derivative and subsequently converting the thus generated amine into a benzazepinone through lactamization reaction.