82756-06-7

Basic information

• Product Name: Acetic acid, 2-oxo-2-[(2-phenylethyl)aMino]-, ethyl ester
• Synonyms: Acetic acid, 2-oxo-2-[(2-phenylethyl)aMino]-, ethyl ester;Ethyl 2-oxo-2-(phenethylamino)acetate
• CAS NO: 82756-06-7
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.2524
• Mol File: 82756-06-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Acetic acid, 2-oxo-2-[(2-phenylethyl)aMino]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, 2-oxo-2-[(2-phenylethyl)aMino]-, ethyl ester(82756-06-7)
• EPA Substance Registry System: Acetic acid, 2-oxo-2-[(2-phenylethyl)aMino]-, ethyl ester(82756-06-7)

Safety Data

• Hazardous Substances Data: 82756-06-7(Hazardous Substances Data)

Usage

General Description

Acetic acid, 2-oxo-2-[(2-phenylethyl)aMino]-, ethyl ester, also known as ethyl 2-oxo-2-[(2-phenylethyl)amino]acetate, is a chemical compound used in various applications. It is a derivative of acetic acid and is commonly used as a flavoring and fragrance ingredient in the food and cosmetic industries. It is also used in the production of pharmaceuticals and as a solvent in organic synthesis. The compound has a fruity, floral scent and is considered to be safe for use in consumer products when used in accordance with regulations and guidelines.

Upstream product

• 64-04-0 phenethylamine 
• 95-92-1 oxalic acid diethyl ester 
• 4755-77-5 Ethyl oxalyl chloride 

Downstream Products

• 22051-02-1 1,1-diphenyl-1,3,4,5-tetrahydro-benz[d]azepin-2-one 
• 88612-00-4 3,4-dihydro-isoquinoline-1-carboxylic acid ethyl ester 
• 1943-82-4 phenethyl isocyanate 

Relevant articles and documents

Supporting-Electrolyte-Free Anodic Oxidation of Oxamic Acids into Isocyanates: An Expedient Way to Access Ureas, Carbamates, and Thiocarbamates

We report a new electrochemical supporting-electrolyte-free method for synthesizing ureas, carbamates, and thiocarbamates via the oxidation of oxamic acids. This simple, practical, and phosgene-free route includes the generation of an isocyanate intermediate in situ via anodic decarboxylation of an oxamic acid in the presence of an organic base, followed by the one-pot addition of suitable nucleophiles to afford the corresponding ureas, carbamates, and thiocarbamates. This procedure is applicable to different amines, alcohols, and thiols. Furthermore, when single-pass continuous electrochemical flow conditions were used and this reaction was run in a carbon graphite Cgr/Cgr flow cell, urea compounds could be obtained in high yields within a residence time of 6 min, unlocking access to substrates that were inaccessible under batch conditions while being easily scalable.

METHOD FOR PRODUCING BENZAZEPINONE

It is an object of the present invention to provide 2-iminocarboxylic acid derivatives, and a practically suitable industrial method for producing benzazepinones in a short process under mild conditions. The present invention provides a method for producing a benzazepinone or a salt thereof, which comprises opening a ring of an isoquinoline derivative and subsequently converting the thus generated amine into a benzazepinone through lactamization reaction.