82756-74-9

Basic information

• Product Name: 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-2-YLMETHANOL
• Synonyms: 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-2-YLMETHANOL;(3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methanol;(3,4-Dihydro-2H-benzo[1,4]oxazin-2-yl)methanol hydrochloride;(3,4-Dihydro-2H-benzo[1,4]oxazin-2-yl)-methanol
• CAS NO: 82756-74-9
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• Mol File: 82756-74-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 329.8°C at 760 mmHg
• Flash Point: 153.3°C
• Appearance: /
• Density: 1.164g/cm³
• Vapor Pressure: 6.96E-05mmHg at 25°C
• Refractive Index: 1.546
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-2-YLMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-2-YLMETHANOL(82756-74-9)
• EPA Substance Registry System: 3,4-DIHYDRO-2H-1,4-BENZOXAZIN-2-YLMETHANOL(82756-74-9)

Safety Data

• Hazardous Substances Data: 82756-74-9(Hazardous Substances Data)

Usage

General Description

3,4-Dihydro-2H-1,4-benzoxazin-2-ylmethanol is a natural product found in plants such as maize and wheat. It belongs to the class of benzoxazinoids, which are known for their defensive properties against pests and pathogens. This chemical has been found to have antifungal, antibacterial, and insecticidal activities, making it of interest for potential use in agricultural and pharmaceutical applications. It is also being studied for its potential effects on human health, as it may have anti-inflammatory and antioxidant properties. Overall, 3,4-Dihydro-2H-1,4-benzoxazin-2-ylmethanol is a versatile chemical with various potential applications in agriculture, medicine, and other industries.

InChI:InChI=1/C9H11NO2/c11-6-7-5-10-8-3-1-2-4-9(8)12-7/h1-4,7,10-11H,5-6H2

Upstream product

• 82756-71-6 3,4-Dihydro-2H-1,4-benzoxazin-2-carbnsaeuremethylester 
• 22244-22-0 ethyl 3,4-dihydro-2H-benzo [b][1,4]oxazine-2-carboxylate 
• 95-55-6 2-amino-phenol 
• 106-89-8 epichlorohydrin 
• 3640-49-1 4-Acetoxy-3,4-dihydro-2H-1,4-benzoxazin-2-carbonsaeuremethylester 

Downstream Products

• 176383-61-2 4-benzoyl-4H-1,4-benzoxazine-2-carbaldehyde 
• 176383-62-3 4-benzyl-4H-1,4-benzoxazine-2-carbaldehyde 
• 68466-18-2 4-benzoyl-4H-1,4-benzoxazine-2-carboxylic acid, ethyl ester 
• 212578-44-4 C-(4-Benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-methylamine 
• 282520-57-4 N-(4-benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-ylmethyl)-4-(1H-indol-3-yl)-butyramide 
• 282520-51-8 toluene-4-sulfonic acid 4-benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-ylmethyl ester 
• 246018-73-5 2-(toluene-4-sulfonyloxymethyl)-2,3-dihydro-benzo[1,4]oxazine-4-carboxylic acid tert-butyl ester 
• 282520-54-1 2-azidomethyl-4-benzyl-3,4-dihydro-2H-benzo[1,4]oxazine 
• 176383-63-4 (4-benzyl-3,4-dihydro-2H-benzo[1,4]oxazin-2-yl)-methanol 

Relevant articles and documents

2,6-Difluorobenzamide Inhibitors of Bacterial Cell Division Protein FtsZ: Design, Synthesis, and Structure–Activity Relationships

A wide variety of drug-resistant microorganisms are continuously emerging, restricting the therapeutic options for common bacterial infections. Antimicrobial agents that were originally potent are now no longer helpful, due to their weak or null activity toward these antibiotic-resistant bacteria. In addition, none of the recently approved antibiotics affect innovative targets, resulting in a need for novel drugs with innovative antibacterial mechanisms of action. The essential cell division protein filamentous temperature-sensitive Z (FtsZ) has emerged as a possible target, thanks to its ubiquitous expression and its homology to eukaryotic β-tubulin. In the latest years, several compounds were shown to interact with this prokaryotic protein and selectively inhibit bacterial cell division. Recently, our research group developed interesting derivatives displaying good antibacterial activities against methicillin-resistant Staphylococcus aureus, as well as vancomycin-resistant Enterococcus faecalis and Mycobacterium tuberculosis. The aim of the present study was to summarize the structure–activity relationships of differently substituted heterocycles, linked by a methylenoxy bridge to the 2,6-difluorobenzamide, and to validate FtsZ as the real target of this class of antimicrobials.

Studies toward the discovery of the next generation of antidepressants. Part 5: 3,4-Dihydro-2H-benzo[1,4]oxazine derivatives with dual 5-HT1A receptor and serotonin transporter affinity

The design, synthesis, and structure-activity relationship of two novel classes of benzoxazine derivatives with dual selective serotonin reuptake inhibitors and 5-HT1A receptor activities are described.

5-phenylpyrrolo-1,4-benzoxazine and 5-phenylpyrrolo-1,4-benzothiazine compounds, process and intermediates for their production and pharmaceutical compositions containing them

Pharmacologically active compounds of formula I STR1 which can be substituted in the phenyl rings and in which R1 denotes hydrogen or lower alkyl, R2 denotes hydrogen or lower alkyl, Y denotes oxygen or sulfur n represents an integer from 1 to 3 Z represents a bond, a CO group or a CH= group, Q denotes nitrogen or the CH group and R7, if Q denotes nitrogen, represents an optionally substituted pyridyl or phenyl radical or, if Q denotes the CH group, represents the N-methyl-N-(4-oxo-3H-pyrimidin-2-yl)amino group, and their acid addition salts and processes and intermediates for their preparation.