82768-44-3Relevant academic research and scientific papers
First ligand-free, microwave-assisted, Heck cross-coupling reaction in pure water on a nucleoside-application to the synthesis of antiviral BVDU
Herv, Gwnalle,Len, Christophe
, p. 46926 - 46929 (2014)
For the first time, a palladium catalyzed Heck cross-coupling reaction between 5-iodo-2′-deoxyuridine and various acrylate derivatives was performed using ligand-free conditions and microwave assistance in pure water. Those new conditions allowed a totally aqueous access to antiviral BVDU in higher yield than that reported (56 vs. 31% for three steps).
Extended fluorescent uridine analogues: synthesis, photophysical properties and selective interaction with BSA protein
Ardhapure, Ajaykumar V.,Bag, Subhendu Sekhar,Bhilare, Shatrughn,Gayakhe, Vijay,Gunturu, Krishna Chaitanya,Kapdi, Anant R.,Sanghvi, Yogesh S.
, p. 14744 - 14754 (2020/09/21)
The improvement in fluorescence properties of 2′-deoxyuridine was brought about by the introduction of (hetero)aromatic moieties at the C-5 position of uridine directly orviaalkenyl/phenyl/styryl linkers to create a library of biologically useful fluorescent nucleosides. The synthesis of these extended nucleoside analogues was carried out using Suzuki-Miyaura and Heck alkenylation reactions. A comparison of their photophysical properties allowed the identification of nucleosides1gand1hthat exhibit the highest quantum yields in an aqueous solution. Studies on the binding interaction of the most promising fluorescent analogues,1gand1h, with serum albumin proteins showed excellent selectivity towards BSA protein over α-amylase. Docking studies were also performed to predict the specific binding site of the nucleosides to BSA.
