82768-44-3Relevant articles and documents
First ligand-free, microwave-assisted, Heck cross-coupling reaction in pure water on a nucleoside-application to the synthesis of antiviral BVDU
Herv, Gwnalle,Len, Christophe
, p. 46926 - 46929 (2014)
For the first time, a palladium catalyzed Heck cross-coupling reaction between 5-iodo-2′-deoxyuridine and various acrylate derivatives was performed using ligand-free conditions and microwave assistance in pure water. Those new conditions allowed a totally aqueous access to antiviral BVDU in higher yield than that reported (56 vs. 31% for three steps).
